Chang Man-Kuang, Chang Leonardo, Kuo Hsiao-Yen, Arango Carlos A
Infectious Diseases, Baptist Health System, Jacksonville, USA.
Biochemistry, University of California Los Angeles, Los Angeles, USA.
Cureus. 2023 Jul 18;15(7):e42063. doi: 10.7759/cureus.42063. eCollection 2023 Jul.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can affect multiple organs due to activation of an inflammatory response. One of the key components of this response is the activation of immunoglobulin A (IgA), thus causing endothelial injury and inflammation. Henoch-Schönlein purpura (HSP) has been rarely reported in adult patients as a complication of the coronavirus disease 2019 (COVID-19) infection. In this report, we present a case of HSP occurring one week after the diagnosis of COVID-19 in a 23-year-old woman. Her symptoms included nausea, vomiting, diffused abdominal pain, joint pain, hematuria, and palpable purpura of the lower extremities. She was treated with intravenous methylprednisolone sodium succinate, followed by oral prednisone therapy, which resulted in clinical improvement, including resolution of abdominal and joint pain as well as skin rashes, without remaining renal complication.
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染可因炎症反应激活而累及多个器官。这种反应的关键组成部分之一是免疫球蛋白A(IgA)的激活,从而导致内皮损伤和炎症。成人患者中,作为2019冠状病毒病(COVID-19)感染的并发症,过敏性紫癜(HSP)鲜有报道。在本报告中,我们介绍了一名23岁女性,在确诊COVID-19一周后发生HSP的病例。她的症状包括恶心、呕吐、弥漫性腹痛、关节疼痛、血尿以及下肢可触及的紫癜。她接受了静脉注射琥珀酸甲泼尼龙治疗,随后口服泼尼松治疗,临床症状得到改善,包括腹部和关节疼痛以及皮疹消退,且未遗留肾脏并发症。