鉴定影响 2 型糖尿病患者二甲双胍应答的临床和药物遗传学因素。

Identification of clinical and pharmacogenetic factors influencing metformin response in Type 2 diabetes mellitus.

机构信息

Department of Health Sciences, University of Burgos, Burgos, Spain.

Research Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, Burgos, Spain.

出版信息

Pharmacogenomics. 2023 Aug;24(12):651-663. doi: 10.2217/pgs-2023-0109. Epub 2023 Aug 23.

DOI:10.2217/pgs-2023-0109

PMID:37610884

Abstract

Metformin, a hypoglycemic drug for Type 2 diabetes mellitus, shows variability in pharmacokinetics and response due to membrane transporters. This study followed 34 Type 2 diabetes mellitus patients on metformin treatment. Genetic variants in 11 metformin transport-related genes were analyzed, revealing associations. Specifically, rs2289669 A/A and rs1050152 T/T genotypes correlated with glycated hemoglobin values at 6 months. rs2289669 G/A genotype influenced glucose levels at 6 months, while rs3889348 A/A, rs2289669 A/A, rs1050152 C/T and rs12943590 A/A genotypes were linked to glucose levels at 12 months. Additionally, rs2032582 C/A and rs2231137 C/T genotypes impacted cholesterol levels at 12 months. These findings shed light on metformin response determinants, offering insights for further research.

摘要

二甲双胍是一种治疗 2 型糖尿病的降血糖药物，由于膜转运体的存在，其药代动力学和反应存在变异性。本研究随访了 34 名接受二甲双胍治疗的 2 型糖尿病患者。分析了 11 个与二甲双胍转运相关基因的遗传变异，发现了相关性。具体来说，rs2289669 A/A 和 rs1050152 T/T 基因型与 6 个月时的糖化血红蛋白值相关。rs2289669 G/A 基因型影响 6 个月时的血糖水平，而 rs3889348 A/A、rs2289669 A/A、rs1050152 C/T 和 rs12943590 A/A 基因型与 12 个月时的血糖水平相关。此外，rs2032582 C/A 和 rs2231137 C/T 基因型影响 12 个月时的胆固醇水平。这些发现揭示了二甲双胍反应的决定因素，为进一步的研究提供了思路。