Nassar Ahmed Amin, Shoaib Abdelrahman Ahmed, Dewidar Hazem Mohammed, Azooz Khaled Omar
Otolaryngology Department, Faculty of Medicine, Cairo University, 4 Mohamed Yousef Othman ST, Al Zohour District, Omraneya, Giza, Cairo, 12552 Arab Republic of Egypt.
Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):1336-1343. doi: 10.1007/s12070-023-03562-2. Epub 2023 Feb 13.
To record the incidence of hypothyroidism in patients after total laryngectomy, whether with or without postoperative radiation therapy and to analyze the effect of hemithyroidectomy for the development of hypothyroidism. A retrospective study included patients who underwent total laryngectomy (with or without hemithyroidectomy) between 2018 and 2021 for laryngeal carcinoma and/or received postoperative radiotherapy. Thirty-six (45%) of the 80 enrolled patients developed hypothyroidism after a median follow-up of 16 months. In this study, adjuvant radiation and central neck dissection were found to be significantly linked with developing post-operative hypothyroidism ( 0.001, 0.007, ). The incidence of hypothyroidism in patients treated for laryngeal carcinoma is high, especially after combination treatment of surgery and radiotherapy.
记录全喉切除术后患者甲状腺功能减退的发生率，无论是否接受术后放射治疗，并分析甲状腺半切术对甲状腺功能减退发生的影响。一项回顾性研究纳入了2018年至2021年间因喉癌接受全喉切除术（有或无甲状腺半切术）和/或接受术后放疗的患者。80名入组患者中，36名（45%）在中位随访16个月后出现甲状腺功能减退。在本研究中，发现辅助放疗和中央区颈部清扫与术后甲状腺功能减退的发生显著相关（P = 0.001，P = 0.007）。喉癌患者甲状腺功能减退的发生率很高，尤其是在手术和放疗联合治疗后。
