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Optimal Management of Status Epilepticus in Children in the Emergency Setting: A Review of Recent Advances.儿童急诊环境中癫痫持续状态的优化管理:近期进展综述
Open Access Emerg Med. 2022 Sep 17;14:491-506. doi: 10.2147/OAEM.S293258. eCollection 2022.
2
Status Epilepticus-Work-Up and Management in Children.儿童癫痫持续状态的检查及处理。
Semin Neurol. 2020 Dec;40(6):661-674. doi: 10.1055/s-0040-1719076. Epub 2020 Nov 5.
3
Status Epilepticus in Children.儿童癫痫持续状态。
J Clin Neurophysiol. 2020 Sep;37(5):429-433. doi: 10.1097/WNP.0000000000000657.
4
Treatment of Refractory Convulsive Status Epilepticus: A Comprehensive Review by the American Epilepsy Society Treatments Committee.难治性惊厥性癫痫持续状态的治疗:美国癫痫协会治疗委员会的全面综述
Epilepsy Curr. 2020 Sep;20(5):245-264. doi: 10.1177/1535759720928269. Epub 2020 Aug 21.
5
Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial.左乙拉西坦、磷苯妥英和丙戊酸钠治疗不同年龄组已确立癫痫持续状态的疗效(ESETT):一项双盲、反应适应性、随机对照试验。
Lancet. 2020 Apr 11;395(10231):1217-1224. doi: 10.1016/S0140-6736(20)30611-5. Epub 2020 Mar 20.
6
Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies.丙戊酸对癫痫患儿骨骼代谢的影响:基于 14 项研究的系统评价和荟萃分析。
BMC Pediatr. 2020 Mar 2;20(1):97. doi: 10.1186/s12887-020-1984-7.
7
Medical management of status epilepticus: Emergency room to intensive care unit.癫痫持续状态的医学处理:从急诊到重症监护病房。
Seizure. 2020 Feb;75:145-152. doi: 10.1016/j.seizure.2019.10.006. Epub 2019 Oct 24.
8
Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial.左乙拉西坦对比苯妥英钠治疗儿童惊厥性癫痫持续状态(ConSEPT)的二线治疗:一项开放标签、多中心、随机对照试验。
Lancet. 2019 May 25;393(10186):2135-2145. doi: 10.1016/S0140-6736(19)30722-6. Epub 2019 Apr 17.
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Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.左乙拉西坦对比苯妥英钠治疗儿童惊厥性癫痫持续状态(EcLiPSE)的二线治疗:一项多中心、开放标签、随机试验。
Lancet. 2019 May 25;393(10186):2125-2134. doi: 10.1016/S0140-6736(19)30724-X. Epub 2019 Apr 17.
10
Conventional and quantitative EEG in status epilepticus.常规和定量脑电图在癫痫持续状态中的应用。
Seizure. 2019 May;68:38-45. doi: 10.1016/j.seizure.2018.09.011. Epub 2018 Oct 6.

不同儿科科室(神经内科、重症监护和急诊医学科)对癫痫持续状态的管理。

Management of Status Epilepticus by Different Pediatric Departments: Neurology, Intensive Care, and Emergency Medicine.

机构信息

Department of Pediatric Neurology, Ankara City Hospital, Ankara, Turkey.

Department of Pediatric Emergency Medicine, Ankara City Hospital, Ankara, Turkey.

出版信息

Eur Neurol. 2023;86(5):315-324. doi: 10.1159/000533191. Epub 2023 Aug 30.

DOI:10.1159/000533191
PMID:37647871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10623395/
Abstract

INTRODUCTION

The aim of this study was to explore the differences in status epilepticus (SE) management among pediatric neurology, emergency medicine, and intensive care specialists in Turkey.

METHODS

A 22-item questionnaire regarding first-, second-, and third-line management strategies of SE including demographic characteristics and common etiologies according to the specialty of participants was mailed to 370 specialists working in Turkey.

RESULTS

A total of 334 participants (response rate 90%) comprising 136 pediatric neurologists, 102 pediatric emergency medicine specialists, and 96 pediatric intensive care specialists completed the survey. While intensive care specialists frequently managed SE due to metabolic and autoimmune reasons, the most common etiologies encountered by emergency medicine specialists were epilepsy and infections. More than half of the intensive care specialists (64.6%) reported using non-BZD antiseizure medications in the 5th minute of the seizure. Most of the neurologists (76.4%) preferred to administer intravenous (IV) levetiracetam infusion as a second-line agent. About half of intensive care specialists and neurologists tried immunomodulatory therapies in super-refractory SE. Intensive care and emergency medicine specialists were less likely to favor ketogenic diet and pyridoxine therapy for the treatment of super-refractory SE. The rate of requesting EEG monitoring to recognize nonconvulsive SE (NCSE) was found to be very low except for neurologists.

CONCLUSION

There was no consensus among neurologists, intensive care specialists, and emergency medicine specialists in the management of SE in Turkey. Familiarity with particular antiseizure medications and the etiologies they manage seem to be the most important factors influencing the attitudes.

摘要

简介

本研究旨在探讨土耳其儿科神经科、急诊医学和重症监护专家在癫痫持续状态(SE)管理方面的差异。

方法

我们向土耳其的 370 名专家邮寄了一份包含 22 个问题的问卷,内容涉及 SE 的一线、二线和三线管理策略,包括参与者专业的人口统计学特征和常见病因。

结果

共有 334 名专家(应答率 90%)完成了调查,包括 136 名儿科神经科医生、102 名儿科急诊医学专家和 96 名儿科重症监护专家。尽管重症监护专家经常因代谢和自身免疫原因管理 SE,但急诊医学专家最常见的病因是癫痫和感染。超过一半的重症监护专家(64.6%)报告在发作的第 5 分钟使用非苯二氮䓬类抗癫痫药物。大多数神经科医生(76.4%)更喜欢使用静脉注射(IV)左乙拉西坦作为二线药物。约一半的重症监护专家和神经科医生在超难治性 SE 中尝试免疫调节治疗。重症监护和急诊医学专家不太倾向于使用生酮饮食和吡哆醇治疗超难治性 SE。除了神经科医生外,请求脑电图监测以识别非惊厥性 SE(NCSE)的比率非常低。

结论

在土耳其,神经科医生、重症监护专家和急诊医学专家在 SE 的管理方面没有达成共识。对特定抗癫痫药物及其管理的病因的熟悉程度似乎是影响态度的最重要因素。