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不同儿科科室(神经内科、重症监护和急诊医学科)对癫痫持续状态的管理。

Management of Status Epilepticus by Different Pediatric Departments: Neurology, Intensive Care, and Emergency Medicine.

机构信息

Department of Pediatric Neurology, Ankara City Hospital, Ankara, Turkey.

Department of Pediatric Emergency Medicine, Ankara City Hospital, Ankara, Turkey.

出版信息

Eur Neurol. 2023;86(5):315-324. doi: 10.1159/000533191. Epub 2023 Aug 30.

Abstract

INTRODUCTION

The aim of this study was to explore the differences in status epilepticus (SE) management among pediatric neurology, emergency medicine, and intensive care specialists in Turkey.

METHODS

A 22-item questionnaire regarding first-, second-, and third-line management strategies of SE including demographic characteristics and common etiologies according to the specialty of participants was mailed to 370 specialists working in Turkey.

RESULTS

A total of 334 participants (response rate 90%) comprising 136 pediatric neurologists, 102 pediatric emergency medicine specialists, and 96 pediatric intensive care specialists completed the survey. While intensive care specialists frequently managed SE due to metabolic and autoimmune reasons, the most common etiologies encountered by emergency medicine specialists were epilepsy and infections. More than half of the intensive care specialists (64.6%) reported using non-BZD antiseizure medications in the 5th minute of the seizure. Most of the neurologists (76.4%) preferred to administer intravenous (IV) levetiracetam infusion as a second-line agent. About half of intensive care specialists and neurologists tried immunomodulatory therapies in super-refractory SE. Intensive care and emergency medicine specialists were less likely to favor ketogenic diet and pyridoxine therapy for the treatment of super-refractory SE. The rate of requesting EEG monitoring to recognize nonconvulsive SE (NCSE) was found to be very low except for neurologists.

CONCLUSION

There was no consensus among neurologists, intensive care specialists, and emergency medicine specialists in the management of SE in Turkey. Familiarity with particular antiseizure medications and the etiologies they manage seem to be the most important factors influencing the attitudes.

摘要

简介

本研究旨在探讨土耳其儿科神经科、急诊医学和重症监护专家在癫痫持续状态(SE)管理方面的差异。

方法

我们向土耳其的 370 名专家邮寄了一份包含 22 个问题的问卷,内容涉及 SE 的一线、二线和三线管理策略,包括参与者专业的人口统计学特征和常见病因。

结果

共有 334 名专家(应答率 90%)完成了调查,包括 136 名儿科神经科医生、102 名儿科急诊医学专家和 96 名儿科重症监护专家。尽管重症监护专家经常因代谢和自身免疫原因管理 SE,但急诊医学专家最常见的病因是癫痫和感染。超过一半的重症监护专家(64.6%)报告在发作的第 5 分钟使用非苯二氮䓬类抗癫痫药物。大多数神经科医生(76.4%)更喜欢使用静脉注射(IV)左乙拉西坦作为二线药物。约一半的重症监护专家和神经科医生在超难治性 SE 中尝试免疫调节治疗。重症监护和急诊医学专家不太倾向于使用生酮饮食和吡哆醇治疗超难治性 SE。除了神经科医生外,请求脑电图监测以识别非惊厥性 SE(NCSE)的比率非常低。

结论

在土耳其,神经科医生、重症监护专家和急诊医学专家在 SE 的管理方面没有达成共识。对特定抗癫痫药物及其管理的病因的熟悉程度似乎是影响态度的最重要因素。

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