Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, Australia.
Montreal Clinical Research Institute, Montreal, Canada.
Exp Hematol. 2023 Nov;127:8-13. doi: 10.1016/j.exphem.2023.08.008. Epub 2023 Aug 28.
Chronic inflammation, although subtle, puts the body in a constant state of alertness and is associated with many diseases, including cancer and cardiovascular diseases. It leads hematopoietic cells to produce and release proinflammatory cytokines, which trigger specific signaling pathways in hematopoietic stem cells (HSCs) that cause changes in proliferation, differentiation, and migration. This response is essential when HSCs are needed to produce specific blood cells to eliminate an intruder, such as a pathogenic virus, but mutant HSCs can use these proinflammatory signals to their advantage and accelerate the development of hematologic disease or malignancy. Understanding this complex process is vital for monitoring and controlling disease progression in patients. In the 2023 International Society for Experimental Hematology winter webinar, Dr. Eric Pietras (University of Colorado Anschutz Medical Campus, United States) and Dr. Katherine Y. King (Baylor College of Medicine, United States) gave a presentation on this topic, which is summarized in this review article.
慢性炎症虽然微妙，但会使身体处于持续警觉状态，并与许多疾病相关，包括癌症和心血管疾病。它导致造血细胞产生并释放促炎细胞因子，这些细胞因子触发造血干细胞 (HSC) 中的特定信号通路，导致增殖、分化和迁移发生变化。当需要 HSC 产生特定的血细胞来清除入侵者（如致病性病毒）时，这种反应至关重要，但突变的 HSC 可以利用这些促炎信号为自己谋取利益，并加速血液疾病或恶性肿瘤的发展。了解这一复杂过程对于监测和控制患者疾病进展至关重要。在 2023 年国际实验血液学会冬季网络研讨会上，Eric Pietras 博士（美国科罗拉多大学安舒茨医疗校区）和 Katherine Y. King 博士（美国贝勒医学院）就这一主题进行了介绍，本文对其进行了总结。
