Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China; Rare Diseases Center, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China; Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100000, China.
Cytokine Growth Factor Rev. 2023 Dec;74:86-99. doi: 10.1016/j.cytogfr.2023.08.007. Epub 2023 Aug 23.
Fibrosis is a pathological condition characterized by the excessive deposition of extracellular matrix components in tissues and organs, leading to progressive architectural remodelling and contributing to the development of various diseases. Osteopontin (OPN), a highly phosphorylated glycoprotein, has been increasingly recognized for its involvement in the progression of tissue fibrosis. This review provides a comprehensive overview of the genetic and protein structure of OPN and focuses on our current understanding of the role of OPN in the development of fibrosis in the lungs and other tissues. Additionally, special attention is given to the potential of OPN as a biomarker and a novel therapeutic target in the treatment of fibrosis.
纤维化是一种病理状态，其特征是组织和器官中细胞外基质成分的过度沉积，导致进行性结构重塑，并促成各种疾病的发展。骨桥蛋白（OPN）是一种高度磷酸化的糖蛋白，其在组织纤维化进展中的作用越来越受到重视。本综述全面概述了 OPN 的遗传和蛋白质结构，并重点介绍了我们目前对 OPN 在肺部和其他组织纤维化发展中的作用的认识。此外，还特别关注了 OPN 作为纤维化治疗中生物标志物和新型治疗靶点的潜力。
