National Clinical Research Center for Child Health of the Children's Hospital, Zhejiang University School of Medicine, No. 3333, Binsheng Rd, Hangzhou, 310052, People's Republic of China.
Department of Gynecology, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, China.
J Transl Med. 2023 Aug 30;21(1):583. doi: 10.1186/s12967-023-04462-3.
Currently, women around the world are still suffering from various female common diseases with the high incidence, such as ovarian cancer, uterine fibroids and preeclampsia (PE), and some diseases are even with the high mortality rate. As a negative feedback regulator in G Protein-Coupled Receptor signaling (GPCR), the Regulator of G-protein Signaling (RGS) protein family participates in regulating kinds of cell biological functions by destabilizing the enzyme-substrate complex through the transformation of hydrolysis of G Guanosine Triphosphate (GTP). Recent work has indicated that, the Regulator of G-protein Signaling 2 (RGS2), a member belonging to the RGS protein family, is closely associated with the occurrence and development of certain female diseases, providing with the evidence that RGS2 functions in sustaining women's health. In this review paper, we summarize the current knowledge of RGS2 in female common diseases, and also tap and discuss its therapeutic potential by targeting multiple mechanisms.
目前，全世界的女性仍在遭受各种女性常见疾病的困扰，这些疾病的发病率较高，如卵巢癌、子宫肌瘤和子痫前期 (PE)，其中一些疾病的死亡率甚至较高。作为 G 蛋白偶联受体信号 (GPCR) 的负反馈调节剂，G 蛋白信号调节因子 (RGS) 蛋白家族通过水解 G 三磷酸鸟苷 (GTP) 来转化酶-底物复合物，从而参与调节多种细胞生物学功能。最近的研究表明，RGS 蛋白家族的成员之一 G 蛋白信号调节因子 2 (RGS2) 与某些女性疾病的发生和发展密切相关，为 RGS2 在维持女性健康方面的作用提供了证据。在这篇综述论文中，我们总结了 RGS2 在女性常见疾病中的现有知识，并通过针对多种机制探讨了其治疗潜力。
