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[上皮细胞与液体和固体脂质膜边缘的相互作用]

[Interaction of epithelial cells with the edges of fluid and solid lipid films].

作者信息

Gordeeva L V, Margolis L B

出版信息

Tsitologiia. 1986 Jul;28(7):699-702.

PMID:3765106
Abstract

Capping of Concanavalin A (Con A) on the surface of epithelial cells near the cell-cell contacts has been compared with that in the regions of cell contacts with the edges of lipid films. If the lipids are in "fluid" state, Con A is capped likely as on the free edges of epithelial sheets, while contacts with the edge of solid lipid film inhibit capping of Con A as do cell-cell contacts. The same is true for capping of liposomes adsorbed on the surface of epithelial cells. We suppose that solid rather than fluid domains in plasma membranes may play a significant role in establishing cell-cell contacts.

摘要

已将伴刀豆球蛋白A(Con A)在靠近细胞 - 细胞接触处的上皮细胞表面的帽化作用与在细胞与脂质膜边缘接触区域的帽化作用进行了比较。如果脂质处于“流体”状态,Con A可能像在上皮片层的自由边缘一样形成帽,而与固体脂质膜边缘的接触会抑制Con A的帽化,细胞 - 细胞接触也是如此。吸附在上皮细胞表面的脂质体的帽化情况也是如此。我们推测质膜中的固体而非流体结构域可能在建立细胞 - 细胞接触中起重要作用。

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