1 型糖尿病患者饮酒与体脂分布的关系。

Associations between alcohol consumption and body fat distribution in type 1 diabetes.

机构信息

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

出版信息

Diabetes Res Clin Pract. 2023 Oct;204:110891. doi: 10.1016/j.diabres.2023.110891. Epub 2023 Aug 30.

DOI:10.1016/j.diabres.2023.110891

PMID:37657645

Abstract

AIM

To evaluate the associations between alcohol consumption and body fat distribution in type 1 diabetes (T1D).

METHODS

DXA assessed the body composition of 548 adults with T1D from the Finnish Diabetic Nephropathy Study. Visceral fat mass (VFM) ≥ 0.7% of body weight for women and ≥ 1.1% for men defined central obesity (CO), whereas body fat mass (BFM) ≥ 40.4% for women and ≥ 31.8% for men defined general obesity (GO). Alcohol consumption data were collected via questionnaires. One standard dose = 12 g of pure alcohol. Participants were classified as abstainers, low-risk, moderate-risk and high-risk alcohol consumers. We used linear and logistic regression models for analyses.

RESULTS

The higher the alcohol consumption the higher the VFM% (r = 0.23, β = 0.083, p = 0.04) in both sexes. BFM% presented a similar pattern in men (r = 0.12, β = 0.160, p = 0.01), but not in women. One weekly dose increase of alcohol consumption increases the odds of CO by 3% (OR 1.03, p = 0.037), but not GO. The odds of CO (OR 7.3, p = 0.003) and GO (OR 5.3, p = 0.007) increase with high-risk, but not with low- and moderate-risk consumptions.

CONCLUSIONS

In adults with T1D, alcohol consumption is linearly associated with VFM% regardless of sex, whereas the association with BFM% is sex-dependent.

摘要

目的

评估 1 型糖尿病（T1D）患者饮酒与体脂分布的关系。

方法

通过 DXA 对来自芬兰糖尿病肾病研究的 548 名 T1D 成年患者的身体成分进行评估。女性内脏脂肪量（VFM）≥0.7%体重和男性 VFM≥1.1%体重定义为中心性肥胖（CO），而女性体脂量（BFM）≥40.4%和男性 BFM≥31.8%定义为一般性肥胖（GO）。通过问卷收集饮酒数据。一个标准剂量=12 克纯酒精。参与者分为不饮酒者、低风险饮酒者、中风险饮酒者和高风险饮酒者。我们使用线性和逻辑回归模型进行分析。

结果

在两性中，饮酒量越高，VFM%越高（r=0.23，β=0.083，p=0.04）。男性 BFM%呈现出类似的模式（r=0.12，β=0.160，p=0.01），但女性则不然。每周增加一次饮酒量会使 CO 的几率增加 3%（OR 1.03，p=0.037），但不会增加 GO 的几率。CO 的几率（OR 7.3，p=0.003）和 GO 的几率（OR 5.3，p=0.007）随着高风险饮酒而增加，但与低风险和中风险饮酒无关。