Al-Nahrain University, College of Medicine, Department of Pathology and Forensic Medicine, Baghdad, Iraq.
Mustansiriyah University, College of Medicine, Department of Pathology and Forensic Medicine, Baghdad, Iraq.
Malays J Pathol. 2023 Aug;45(2):229-236.
Ovarian cancer is one of leading causes of cancer related death in gynecology. CD117 is a tyrosine kinase receptor that plays an important role in regulation of apoptosis, cell proliferation and adhesion by binding to its ligand-stem cell factor. Recent studies demonstrated its aberrant overexpression in various malignancies and concluded that it may play a pivotal role in carcinogenesis.
To evaluate CD117 expression in ovarian surface epithelial tumours.
This retrospective study included 30 ovarian epithelial borderline, low and highly malignant tumours' formalin-fixed paraffin-blocks (FFPE) tissue blocks. Tissue sections were subjected to the routine haematoxylin-eosin stain and with the anti-CD117 immunohistochemically.
There is a high significant difference in CD117 expression between borderline and malignant groups (P = 0.001). Additionally, there was significant difference in expression in relation to histopathological type (serous versus non-serous) in low-grade and the high-grade ovarian surface epithelial tumours (p=0.04, p=0.035 respectively). Tumour grade and stage strongly correlates with CD117 expression (p=0.014, p=0.019 respectively).
We concluded that CD117 expression was significantly correlated with higher ovarian tumour grade and stage.
卵巢癌是妇科癌症相关死亡的主要原因之一。CD117 是一种酪氨酸激酶受体，通过与其配体-干细胞因子结合，在调节细胞凋亡、增殖和黏附中发挥重要作用。最近的研究表明，它在各种恶性肿瘤中存在异常过表达，并得出结论，它可能在肿瘤发生中发挥关键作用。
评估卵巢表面上皮肿瘤中 CD117 的表达。
本回顾性研究包括 30 例卵巢上皮性交界性、低级别和高级别恶性肿瘤的福尔马林固定石蜡包埋（FFPE）组织块。组织切片进行常规苏木精-伊红染色，并进行抗 CD117 免疫组织化学染色。
在交界性和恶性组之间，CD117 表达存在显著差异（P = 0.001）。此外，在低级别和高级别卵巢表面上皮性肿瘤中，CD117 表达与组织病理学类型（浆液性与非浆液性）之间存在显著差异（p=0.04，p=0.035）。肿瘤分级和分期与 CD117 表达强烈相关（p=0.014，p=0.019）。
我们得出结论，CD117 表达与卵巢肿瘤分级和分期较高显著相关。
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