Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.
Biol Reprod. 2023 Dec 11;109(6):785-798. doi: 10.1093/biolre/ioad105.
Infertility is a challenging health problem that affects 8-15% of couples worldwide. Establishing pregnancy requires successful embryo implantation, but about 85% of unsuccessful pregnancies are due to embryo implantation failure or loss soon after. Factors crucial for successful implantation include invasive blastocysts, receptive endometrium, invasion of trophoblast cells, and regulation of immune tolerance at the maternal-fetal interface. Maternal-fetal crosstalk, which relies heavily on protein-protein interactions, is a critical factor in implantation that involves multiple cellular communication and molecular pathways. Glycosylation, a protein modification process, is closely related to cell growth, adhesion, transport, signal transduction, and recognition. Protein glycosylation plays a crucial role in maternal-fetal crosstalk and can be divided into N-glycosylation and O-glycosylation, which are often terminated by sialylation or fucosylation. This review article examines the role of protein glycosylation in maternal-fetal crosstalk based on two transcriptome datasets from the GEO database (GSE139087 and GSE113790) and existing research, particularly in the context of the mechanism of protein glycosylation and embryo implantation. Dysregulation of protein glycosylation can lead to adverse pregnancy outcomes, such as missed abortion and recurrent spontaneous abortion, underscoring the importance of a thorough understanding of protein glycosylation in the diagnosis and treatment of female reproductive disorders. This knowledge could have significant clinical implications, leading to the development of more effective diagnostic and therapeutic approaches for these conditions.
不孕不育是一个全球性的医学难题，影响着全球 8-15%的夫妇。建立妊娠需要成功的胚胎着床，但约 85%的失败妊娠是由于胚胎着床失败或着床后不久的损失。成功着床的关键因素包括侵袭性囊胚、接受性子宫内膜、滋养层细胞的侵袭以及母胎界面免疫耐受的调节。母胎细胞间的通讯依赖于蛋白质-蛋白质的相互作用，是着床过程中的一个关键因素，涉及到多种细胞通讯和分子途径。糖基化是一种蛋白质修饰过程，与细胞生长、黏附、运输、信号转导和识别密切相关。蛋白质糖基化在母胎细胞间的通讯中起着至关重要的作用，可以分为 N-糖基化和 O-糖基化，通常由唾液酸化或岩藻糖化终止。本文基于 GEO 数据库中的两个转录组数据集（GSE139087 和 GSE113790）和现有研究，综述了蛋白质糖基化在母胎细胞间通讯中的作用，特别是在蛋白质糖基化和胚胎着床机制方面。蛋白质糖基化的失调可能导致不良的妊娠结局，如稽留流产和复发性自然流产，这凸显了深入了解蛋白质糖基化在女性生殖障碍的诊断和治疗中的重要性。这一知识可能具有重要的临床意义，为这些疾病的诊断和治疗方法的发展提供了更有效的途径。
