Fondazione Policlinico Universitario 'Agostino Gemelli' - IRCSS, 00168 Rome, Italy; Università Cattolica del Sacro Cuore, Institute of Neurology, 00168 Rome, Italy.
Fondazione Policlinico Universitario 'Agostino Gemelli' - IRCSS, 00168 Rome, Italy.
Neurologia (Engl Ed). 2023 Sep;38(7):467-474. doi: 10.1016/j.nrleng.2021.01.006.
and Sex and cognitive profile may be related to the laterality of motor symptoms in idiopathic Parkinson's disease.
Parkinson's disease (PD) is well recognised as an inherently asymmetric disease with unilateral onset of motor symptoms. The laterality of motor symptoms may be linked to sex, clinical and demographic variables, and neuropsychological disorders. However, the available data are inconsistent. This study aimed to explore the potential association between the laterality of motor symptoms and clinical and demographic variables and deficits in specific cognitive domains.
We retrospectively recruited 97 participants with idiopathic PD without dementia; 60 presented motor symptoms on the left side and 37 on the right side. Both groups were comparable in terms of age, age at disease onset, disease duration, and severity of the neurological deficits according to the Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr scale.
Participants with left-side motor symptoms scored lower on the Schwab and England Activities of Daily Living scale. Our sample included more men than women (67% vs. 33%). Both sexes were not equally represented in the 2 groups: there were significantly more men than women in the group of patients with left-side motor symptoms (77% vs. 23%), whereas the percentages of men and women in the group of patients with right-side motor symptoms were similar (51% vs. 49%). Both groups performed similarly in all neuropsychological tasks, but women, independently of laterality, performed better than men in the naming task.
We found a clear prevalence of men in the group of patients with left-side motor symptoms; this group also scored lower on the Schwab and England Scale. Female sex was predictive of better performance in the naming task. Sex should always be considered in disorders that cause asymmetric involvement of the brain, such as PD.
性别和认知特征可能与特发性帕金森病的运动症状的偏侧性有关。
帕金森病（PD）是一种公认的固有不对称疾病，其运动症状呈单侧起病。运动症状的偏侧性可能与性别、临床和人口统计学变量以及神经心理障碍有关。然而，现有的数据并不一致。本研究旨在探讨运动症状的偏侧性与临床和人口统计学变量以及特定认知领域缺陷之间的潜在关联。
我们回顾性招募了 97 名无痴呆的特发性 PD 患者；60 名患者的运动症状出现在左侧，37 名患者的运动症状出现在右侧。根据统一帕金森病评定量表（Unified Parkinson's Disease Rating Scale）和 Hoehn 和 Yahr 量表，两组在年龄、发病年龄、疾病持续时间和神经功能缺损严重程度方面无差异。
左侧运动症状患者的 Schwab 和 England 日常生活活动量表评分较低。我们的样本中男性多于女性（67%比 33%）。两组在性别上的分布并不均衡：左侧运动症状组的男性明显多于女性（77%比 23%），而右侧运动症状组的男性和女性比例相似（51%比 49%）。两组在所有神经心理学任务中的表现相似，但无论偏侧性如何，女性在命名任务中的表现均优于男性。
我们发现左侧运动症状患者组中男性的患病率明显较高；该组在 Schwab 和 England 量表上的评分也较低。女性性别是命名任务表现较好的预测因素。在导致大脑不对称性受累的疾病（如 PD）中，性别应始终被考虑。
