Khizar Hayat, Hu Yufei, Wu Yanhua, Yang Jianfeng
Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of medicine, 310006, Hangzhou, Zhejiang, China.
Department of Oncology, The Fourth Affiliated Hospital, International Institute of Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Cell Death Discov. 2023 Sep 4;9(1):332. doi: 10.1038/s41420-023-01631-7.
Cholangiocarcinoma (CCA) is a malignant tumor that originates from the biliary epithelial cells. It is characterized by a difficult diagnosis and limited treatment options. Autophagy is a cellular survival mechanism that maintains nutrient and energy homeostasis and eliminates intracellular pathogens. It is involved in various physiological and pathological processes, including the development of cancer. However, the role, mechanism, and potential therapeutic targets of autophagy in CCA have not been thoroughly studied. In this review, we introduce the classification, characteristics, process, and related regulatory genes of autophagy. We summarize the regulation of autophagy on the progression of CCA and collect the latest research progress on some autophagy modulators with clinical potential in CCA. In conclusion, combining autophagy modulators with immunotherapy, chemotherapy, and targeted therapy has great potential in the treatment of CCA. This combination may be a potential therapeutic target for CCA in the future.
胆管癌（CCA）是一种起源于胆管上皮细胞的恶性肿瘤。其特点是诊断困难且治疗选择有限。自噬是一种细胞存活机制，可维持营养和能量稳态并清除细胞内病原体。它参与各种生理和病理过程，包括癌症的发展。然而，自噬在CCA中的作用、机制和潜在治疗靶点尚未得到充分研究。在本综述中，我们介绍了自噬的分类、特征、过程和相关调控基因。我们总结了自噬对CCA进展的调控，并收集了一些在CCA中具有临床潜力的自噬调节剂的最新研究进展。总之，将自噬调节剂与免疫疗法、化疗和靶向疗法相结合在CCA治疗中具有巨大潜力。这种联合可能是未来CCA的潜在治疗靶点。
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