Swope Samuel D, Jones Tyler W, Mellina Kevin N, Nichols Sarah J, DiAngelo Justin R
Pennsylvania State University, Berks Campus, Reading, PA.
MicroPubl Biol. 2023 Aug 22;2023. doi: 10.17912/micropub.biology.000945. eCollection 2023.
Achieving metabolic homeostasis is necessary for survival, and many genes are required to control organismal metabolism. A genetic screen in larvae identified putative fat storage genes including . has been shown to act in neurons to regulate larval lipid storage; however, whether functions to regulate adult metabolism is unknown. males store more fat than controls while both groups eat similar amounts. flies express more brummer lipase and less of the glycolytic enzyme triose phosphate isomerase, which may contribute to excess fat observed in these mutants. These results suggest that regulates adult lipid homeostasis.
实现代谢稳态是生存所必需的,并且需要许多基因来控制机体代谢。在幼虫中进行的一项基因筛选鉴定出了包括……在内的假定脂肪储存基因。……已被证明在神经元中发挥作用以调节幼虫脂质储存;然而,它是否在调节成虫代谢中发挥作用尚不清楚。……雄性比对照组储存更多脂肪,而两组的食量相似。……果蝇表达更多的布勒默脂肪酶,而糖酵解酶磷酸丙糖异构酶的表达较少,这可能导致在这些突变体中观察到脂肪过多。这些结果表明……调节成虫脂质稳态。