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美国南部一家诊所中 HIV 青少年的病毒载量和性传播感染检测。

Viral load and sexually transmitted infection testing among youth with HIV in a southern United States clinic.

机构信息

College of Nursing, Florida State University, Tallahassee, FL, USA.

School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.

出版信息

Int J STD AIDS. 2024 Jan;35(1):11-17. doi: 10.1177/09564624231200917. Epub 2023 Sep 7.

Abstract

As compared to their older peers, youth with HIV (YWH) are less likely to attain viral suppression and have higher rates of sexually transmitted infections (STI). In this exploratory study, we examine the relationship between HIV viral suppression, STI testing, and STI diagnosis among YWH receiving care at a clinic in the southern United States. Data from 933 clinical visits (2017-2020) were aggregated into singular patient records for YWH aged 10-24 years in Alabama ( = 139). Analyses included univariate generalized linear mixed models performed with the PROC GLIMMIX procedure approximating the marginal likelihood by using Laplace's method. Sample median age was 22 years at the index visit. Most YWH were 20-24 years old (69.1%), male (67.6%), and identified as Black (77%); 58.3% were virally unsuppressed at index visit. YWH who identified as White or of other races had 4.79 times higher odds of being virally suppressed as compared to Black YWH ( < .01); STI testing behavior and STI positive diagnosis were associated with lower odds of being virally suppression. Findings suggest that among YWH, receiving STI testing and having an STI diagnosis is associated with a lack of viral suppression, suggesting that extra efforts may be necessary to support YWH who have an STI to attain suppression. Research is needed to examine individual behaviors, structural forces, and clinic features that could impact STI care engagement, specifically among unsuppressed YWH.

摘要

与年长的同龄人相比,感染艾滋病毒的年轻人(YWH)不太可能实现病毒抑制,并且性传播感染(STI)的发病率更高。在这项探索性研究中,我们检查了在美国南部一家诊所接受治疗的 YWH 中 HIV 病毒抑制、STI 检测和 STI 诊断之间的关系。将来自 933 次临床就诊(2017-2020 年)的数据汇总到阿拉巴马州年龄在 10-24 岁的 YWH 的单个患者记录中(n = 139)。分析包括使用 PROC GLIMMIX 程序进行的单变量广义线性混合模型,该程序使用拉普拉斯方法近似边缘似然。样本中位数年龄为索引就诊时的 22 岁。大多数 YWH 为 20-24 岁(69.1%),男性(67.6%),并被认定为黑人(77%);58.3%的人在索引就诊时病毒未被抑制。与黑人 YWH 相比,自我认同为白人或其他种族的 YWH 实现病毒抑制的可能性高出 4.79 倍(<0.01);进行 STI 检测和 STI 阳性诊断与降低病毒抑制的可能性相关。研究结果表明,在 YWH 中,进行 STI 检测和患有 STI 与缺乏病毒抑制有关,这表明可能需要额外的努力来支持患有 STI 的 YWH 实现抑制。需要研究来检查可能影响 STI 护理参与的个体行为、结构力量和诊所特征,特别是在未被抑制的 YWH 中。

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