MenACWY-TT 在现实世界中的影响和效果。
Real-world impact and effectiveness of MenACWY-TT.
机构信息
Department of Pediatrics, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Infectious Diseases Unit, Hospital de niños Dr. Exequiel González Cortés, Santiago, Chile.
出版信息
Hum Vaccin Immunother. 2023 Aug 1;19(2):2251825. doi: 10.1080/21645515.2023.2251825.
In response to escalating cases of serogroup W (MenW) invasive meningococcal disease (IMD), multiple countries introduced quadrivalent conjugate MenACWY vaccines into their national immunization programs (NIPs). Here, we summarize the real-world impact and vaccine effectiveness (VE) data of MenACWY-TT from Chile, England, the Netherlands, and Australia. Incidence rate reductions (IRRs) and VE from baseline to post-NIP period were extracted from publications or calculated. After the administration of a single dose of MenACWY-TT, substantial IRRs of MenCWY were observed across the countries in vaccine-eligible age groups (83%-85%) and via indirect protection in non-vaccine-eligible age groups (45%-53%). The impact of MenACWY-TT was primarily driven by MenW IRRs, as seen in vaccine-eligible age groups (65%-92%) and non-vaccine-eligible age groups (41%-57%). VE against MenW was reported in vaccine-eligible toddlers (92%) in the Netherlands and in vaccine-eligible adolescents/young adults (94%) in England. These real-world data support the implementation and continued use of MenACWY-TT in NIPs.
针对血清群 W（MenW）侵袭性脑膜炎球菌病（IMD）病例不断上升的情况，多个国家在国家免疫计划（NIP）中引入了四价结合型 MenACWY 疫苗。在此，我们总结了智利、英国、荷兰和澳大利亚的 MenACWY-TT 的真实世界影响和疫苗有效性（VE）数据。从出版物中提取或计算了从基线到 NIP 后期间的发病率降低率（IRR）和 VE。在接种了单剂 MenACWY-TT 后，在疫苗可及年龄组（83%-85%）和非疫苗可及年龄组（45%-53%）中观察到了针对 MenCWY 的大量 IRR。MenACWY-TT 的影响主要是由 MenW 的 IRR 驱动的，这在疫苗可及年龄组（65%-92%）和非疫苗可及年龄组（41%-57%）中可见。在荷兰，疫苗可及的幼儿（92%）和英国，疫苗可及的青少年/年轻人（94%）中报告了针对 MenW 的 VE。这些真实世界的数据支持在 NIP 中实施和继续使用 MenACWY-TT。
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