一种新型前血管活性肠肽衍生肽的表征

Characterization of a novel prepro VIP derived peptide.

作者信息

Yiangou Y, Requejo F, Polak J M, Bloom S R

出版信息

Biochem Biophys Res Commun. 1986 Sep 30;139(3):1142-9. doi: 10.1016/s0006-291x(86)80296-0.

Abstract

A newly identified, large molecular weight form of peptide histidine methionine (PHM), has been found not only where it was first revealed, in the stomach, but also in high concentrations in the nasal mucosa and urogenital system, though not in the central nervous system, intestine and lung. An antibody to the spacer peptide sequence prepro-VIP 111-122, lying between PHM and VIP, also reacts directly with the large molecular form of PHM. It is suggested that the post-translational processing of prepro-VIP differs between tissues and in some, cleavage may not occur at the C-terminal end of PHM. The biological significance of this is currently unclear.

摘要

一种新发现的、大分子量形式的肽组氨酸甲硫氨酸（PHM），不仅在其最初被发现的胃部存在，而且在鼻粘膜和泌尿生殖系统中也有高浓度存在，不过在中枢神经系统、肠道和肺部中未发现。一种针对位于PHM和血管活性肠肽（VIP）之间的间隔肽序列前体VIP 111 - 122的抗体，也能直接与大分子量形式的PHM发生反应。这表明前体VIP的翻译后加工在不同组织间存在差异，在某些组织中，可能不会在PHM的C末端发生切割。其生物学意义目前尚不清楚。