新型抗叶酸剂N10-炔丙基-5,8-二氮杂叶酸（CB3717）治疗恶性间皮瘤的II期研究 - Suppr

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Phase II study of a novel antifolate, N10-propargyl-5,8 dideazafolic acid (CB3717), in malignant mesothelioma.

作者信息

Cantwell B M, Earnshaw M, Harris A L

出版信息

Cancer Treat Rep. 1986 Nov;70(11):1335-6.

PMID:3768876

Abstract

摘要

相似文献

Phase II study of a novel antifolate, N10-propargyl-5,8 dideazafolic acid (CB3717), in malignant mesothelioma.新型抗叶酸剂N10-炔丙基-5,8-二氮杂叶酸（CB3717）治疗恶性间皮瘤的II期研究

Cancer Treat Rep. 1986 Nov;70(11):1335-6.

Phase II study of the antifolate N10-propargyl-5,8-dideazafolic acid (CB 3717) in advanced breast cancer.

Eur J Cancer Clin Oncol. 1988 Apr;24(4):733-6. doi: 10.1016/0277-5379(88)90307-0.

Phase II study of the thymidylate synthetase inhibitor CB3717 (N10-propargyl-5,8-dideazafolic acid) in colorectal cancer.胸苷酸合成酶抑制剂CB3717（N10-炔丙基-5,8-二去氮叶酸）用于结直肠癌的II期研究。

Br J Cancer. 1988 Jun;57(6):628-9. doi: 10.1038/bjc.1988.143.

Recent preclinical and clinical studies with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB 3717).

NCI Monogr. 1987(5):213-8.

A phase I evaluation of the quinazoline antifolate thymidylate synthase inhibitor, N10-propargyl-5,8-dideazafolic acid, CB3717.喹唑啉抗叶酸胸苷酸合成酶抑制剂N10-炔丙基-5,8-二去氮叶酸（CB3717）的I期评估。

J Clin Oncol. 1986 Aug;4(8):1245-52. doi: 10.1200/JCO.1986.4.8.1245.

Phase I study of the antifolate N10-propargyl-5,8-dideazafolic acid, CB 3717.

Eur J Cancer Clin Oncol. 1988 Apr;24(4):769-75. doi: 10.1016/0277-5379(88)90313-6.

A phase I evaluation of N10-propargyl-5,8-dideazafolic acid.

Eur J Cancer Clin Oncol. 1988 Feb;24(2):201-4. doi: 10.1016/0277-5379(88)90253-2.

Polyglutamation of the antifolate anticancer drug N10-propargyl-5,8-dideazafolic acid (CB 3717) in the mouse.抗叶酸抗癌药物N10-炔丙基-5,8-二去氮叶酸（CB 3717）在小鼠体内的多聚谷氨酸化作用

Anticancer Res. 1986 Jul-Aug;6(4):807-12.

The efficacy of 5-fluorouracil in human colorectal cancer is not enhanced by thymidylate synthetase inhibition with CB3717 (N10-propargyl-5,8 dideazafolic acid).CB3717（N10-炔丙基-5,8-二去氮叶酸）抑制胸苷酸合成酶并不能增强5-氟尿嘧啶对人类结直肠癌的疗效。

Br J Cancer. 1988 Aug;58(2):189-90. doi: 10.1038/bjc.1988.190.

Moderate antiproliferative effect of the antifolate CB3717 in the BN myeloid leukaemia model.抗叶酸药物CB3717在BN髓性白血病模型中具有中度抗增殖作用。

Br J Cancer. 1988 Apr;57(4):405-7. doi: 10.1038/bjc.1988.91.

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From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates.从甲氨蝶呤到培美曲塞及其他。抗叶酸药物的药效学和临床特性综述。

Invest New Drugs. 2006 Jan;24(1):37-77. doi: 10.1007/s10637-005-4541-1.

A phase II study of the platinum analogues JM8 and JM9 in malignant pleural mesothelioma.铂类类似物JM8和JM9用于恶性胸膜间皮瘤的II期研究。

Cancer Chemother Pharmacol. 1986;18(3):286-8. doi: 10.1007/BF00273405.

Moderate antiproliferative effect of the antifolate CB3717 in the BN myeloid leukaemia model.抗叶酸药物CB3717在BN髓性白血病模型中具有中度抗增殖作用。

Br J Cancer. 1988 Apr;57(4):405-7. doi: 10.1038/bjc.1988.91.

Chemotherapy in malignant mesothelioma: a review.恶性间皮瘤的化疗：综述

Cancer Chemother Pharmacol. 1991;28(5):319-30. doi: 10.1007/BF00685684.

An extended phase II trial of ifosfamide plus mesna in malignant mesothelioma.异环磷酰胺联合美司钠治疗恶性间皮瘤的扩展II期试验。

Invest New Drugs. 1992 Nov;10(4):337-43. doi: 10.1007/BF00944192.

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