针刺联合米非司酮可改善子宫肌瘤患者的性激素和炎症因子水平。
Acupuncture combined with mifepristone improves sex hormones and inflammatory factors in patients with uterine fibroids.
作者信息
Yao Liping, Liu Guoqiang, Li Ting, Wang Liping, Lun Yi, Wang Xiaoxia, Xu Haiyang, Bai Zhiying
机构信息
Department of Gynaecology, Shaanxi Weibei Central Hospital North Section of West Second Ring Road, Dali County, Weinan 715100, Shaanxi, China.
Acupuncture and Moxibustion Department I, Shaanxi Provincial Hospital of Chinese Medicine No. 4, Xihuamen, Xi'an 710003, Shaanxi, China.
出版信息
Am J Transl Res. 2023 Aug 15;15(8):5519-5527. eCollection 2023.
OBJECTIVE
To analyze the therapeutic effect of acupuncture combined with mifepristone on uterine fibroids and its influence on sex hormones and inflammatory factors.
METHODS
Data of 102 patients with uterine fibroids admitted to Shanxi Provincial Hospital of Chinese Medicine from January 2019 to January 2022 were retrospectively analyzed. Among them, there were 50 patients treated with mifepristone alone (control group) and 52 patients undergoing combined treatment of acupuncture and mifepristone (observation group). After 2 months of continuous treatment, the therapeutic efficacy, volume of uterine fibroids and uterus, levels of inflammatory factors (C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α)), as well as levels of estradiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), along with hemodynamic levels and incidence of adverse reactions were recorded and compared between the two groups. Logistic analysis was employed to identify the independent risk factors for the recurrence of uterine fibroids in patients.
RESULTS
Compared with the control group, the observation group was identified with significantly higher overall response rate (P < 0.05). The uterine fibroid volume and uterine volume significantly improved in both groups after treatment, and the improvements were more prominent in the observation group than in the control group (P < 0.05). After treatment, the serum CRP and TNF-α were both evidently decreased in the two groups, while levels of E2, FSH, LH and peak blood flow velocity were significantly ameliorated, and the improvements in the observation group were more significant than those in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Alcohol intake and treatment regime were independent risk factors for the recurrence of uterine fibroids in patients.
CONCLUSION
Combining acupuncture with mifepristone can significantly improve uterine fibroids, estrogen and progesterone levels, as well as reduce inflammation, with a high level of safety, making it a promising treatment for clinical use.
目的
分析针刺联合米非司酮治疗子宫肌瘤的疗效及其对性激素和炎症因子的影响。
方法
回顾性分析2019年1月至2022年1月山西省中医院收治的102例子宫肌瘤患者的资料。其中，单纯米非司酮治疗患者50例（对照组），针刺联合米非司酮治疗患者52例（观察组）。连续治疗2个月后，记录并比较两组的治疗效果、子宫肌瘤及子宫体积、炎症因子（C反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α））水平、雌二醇（E2）、促卵泡生成素（FSH）和促黄体生成素（LH）水平、血流动力学水平及不良反应发生率。采用Logistic分析确定患者子宫肌瘤复发的独立危险因素。
结果
与对照组相比，观察组总有效率显著更高（P<0.05）。两组治疗后子宫肌瘤体积和子宫体积均显著改善，且观察组改善更明显（P<0.05）。治疗后，两组血清CRP和TNF-α均明显降低，E2、FSH、LH水平及峰值血流速度显著改善，且观察组改善更显著（P<0.05）。两组不良反应发生率比较，差异无统计学意义（P>0.05）。饮酒和治疗方案是患者子宫肌瘤复发的独立危险因素。
结论
针刺联合米非司酮可显著改善子宫肌瘤、雌激素和孕激素水平，并减轻炎症，安全性高，是一种很有前景的临床治疗方法。
Zotero 插件