电解氧化水作为牙科医疗保健中的多用途杀菌剂：范围综述。
Electrolysed oxidising water as a multi-purpose biocide in dental healthcare-A scoping review.
机构信息
Department of Oral Sciences, Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Department of Oral Rehabilitation, Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
出版信息
Gerodontology. 2023 Dec;40(4):422-462. doi: 10.1111/ger.12712. Epub 2023 Sep 11.
OBJECTIVES
The objective of this scoping review was to map evidence of electrolysed oxidising water (EOW) as a biocide for dental applications of relevance to older people and identify research gaps.
BACKGROUND
EOW is an emerging, "green," and cost-effective biocide. There are no reviews on the landscape of EOW research as either an antiseptic or disinfectant in dental healthcare or its suitability for the oral healthcare of older people.
MATERIALS AND METHODS
The review follows the PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines. Database searches (Google Scholar, PubMed, Web of Science, Ovid, Scopus and Science Direct) were undertaken using MESH terms and Boolean operators with no date restrictions, to identify full-text, original reports published in English-language peer-reviewed journals.
RESULTS
The search yielded 114 papers that met the inclusion/exclusion criteria. Dental applications of EOW include its use as an endodontic irrigant (39%); mouth rinse/surgical irrigant (21%); disinfectant for dental unit water lines (19%) and dental biomaterials (17%); and for antimicrobial efficacy, effects on oral tissues and on dental material properties. Most studies (83%) evaluated a single EOW formulation (acidic, moderately acidic or neutral) that was either generated at 'point-of-use' (POU; 72%), bottled ('ready-to-use', RTU; 24%) or from unspecified (3%) sources. Six reports evaluated storage-related parameters and 25 evaluated clinical applications; 89 were in vitro studies and one investigated the cost-effectiveness of POU EOW.
CONCLUSIONS
Neutral-pH, EOW is effective as an antimicrobial agent without deleterious effects on oral tissues. However, research on the impact of storage conditions, anti-Candida biofilm efficacy and mechanism of action against yeasts, long-term effects on denture materials and cost-effectiveness is required to establish the suitability of EOW as a multipurpose biocide for dental healthcare, including infection-control requirements relating to older people.
目的
本范围综述旨在绘制电解氧化水 (EOW) 作为一种杀生物剂在与老年人相关的牙科应用中的证据，并确定研究空白。
背景
EOW 是一种新兴的、“绿色”且具有成本效益的杀生物剂。没有关于 EOW 作为防腐剂或消毒剂在牙科保健中的应用或其在老年人口腔保健中的适用性的综述。
材料和方法
本综述遵循 PRISMA 扩展范围综述 (PRISMA-ScR) 指南。使用 MESH 术语和布尔运算符进行数据库搜索（Google Scholar、PubMed、Web of Science、Ovid、Scopus 和 Science Direct），没有日期限制，以确定全文、发表在英文同行评审期刊上的原始报告。
结果
搜索结果产生了 114 篇符合纳入/排除标准的论文。EOW 的牙科应用包括将其用作根管冲洗液（39%）；漱口/手术冲洗液（21%）；用于牙科设备水线（19%）和牙科生物材料（17%）的消毒剂；以及用于抗菌功效、对口腔组织的影响和对牙科材料特性的影响。大多数研究（83%）评估了单一的 EOW 配方（酸性、中度酸性或中性），这些配方是在“就地”生成的（72%）、瓶装的（“即用型”，RTU；24%）或来源不明的（3%）。有 6 份报告评估了储存相关参数，25 份报告评估了临床应用；89 份是体外研究，一份报告评估了 POEOW 的成本效益。
结论
中性 pH 值的 EOW 作为一种抗菌剂是有效的，且对口腔组织没有有害影响。然而，需要研究储存条件、抗白色念珠菌生物膜功效和对酵母的作用机制以及长期对义齿材料的影响以及成本效益，以确定 EOW 作为一种多用途杀生物剂在牙科保健中的适用性，包括与老年人相关的感染控制要求。
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