Ki Au Yik, Ma Qiangqiang, Zhang Jie, Xie Zuowei
Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong Shatin, N.T., Hong Kong, P.R. China.
Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen, 518055, P.R.China.
Chem Asian J. 2023 Oct 17;18(20):e202300611. doi: 10.1002/asia.202300611. Epub 2023 Sep 21.
An efficient and convenient strategy for Ir-catalyzed selective B(3)-amination of o-carboranes with amines via acceptorless BH/NH dehydrocoupling was developed, affording a series of B(3)-aminated-o-carboranes in moderate to high isolated yields with H gas as a sole by-product. Such an oxidant-free system endues the protocol sustainability, atom-economy and environmental friendliness. A reaction mechanism via an Ir(I)-Ir(III)-Ir(I) catalytic cycle involving oxidative addition, dehydrogenation and reductive elimination was proposed.
开发了一种高效便捷的策略，通过无受体的BH/NH脱氢偶联反应，实现铱催化邻碳硼烷与胺的选择性B(3)-胺化反应，以氢气作为唯一副产物，中等至较高的分离产率得到一系列B(3)-胺化邻碳硼烷。这种无氧化剂体系赋予该方法可持续性、原子经济性和环境友好性。提出了一种通过Ir(I)-Ir(III)-Ir(I)催化循环的反应机理，涉及氧化加成、脱氢和还原消除。
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