、、和基因多态性对巴西患者华法林维持剂量的影响。
Influence of polymorphisms in , , and genes on the warfarin maintenance dose in Brazilian patients.
作者信息
de Freitas Campos Emílio Itamar, Gomes Karina Braga, Ribeiro Daniel Dias, Puurunen Marja Kaarina, Oliveira Magalhães Mourão Aline de, Ferreira Isadora Gonçalves, da Costa Rocha Manoel Otávio, de Souza Renan Pedra, Parreiras Martins Maria Auxiliadora
机构信息
Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, 30130-100, Brasil.
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brasil.
出版信息
Pharmacogenomics. 2023 Aug;24(13):701-712. doi: 10.2217/pgs-2023-0099. Epub 2023 Sep 13.
Polymorphisms in the , , and genes may impact warfarin dose. To investigate the influence of sociodemographic, clinical factors and polymorphisms , and for , -1639G>A for , 3435C>T for , and ϵ2, ϵ3 and ϵ4 for genes on the mean weekly warfarin maintenance dose in adults. This cross-sectional study recruited a calculated sample of 315 patients in three anticoagulation clinics in Brazil. A model containing the variables significantly associated with warfarin dose was estimated. The mean age of patients was 64.1 ± 13.1 years, with 173 (54.9%) women. Age, use of amiodarone, genotype GA, genotype AA, genotypes or and genotypes or or were associated with a reduced warfarin dose. This study pointed out factors that could impact the management of oral anticoagulation.
、、和基因的多态性可能会影响华法林的剂量。为了研究社会人口统计学、临床因素以及、和基因的多态性（基因的-1639G>A、基因的3435C>T以及基因的ε2、ε3和ε4）对成人华法林平均每周维持剂量的影响。这项横断面研究在巴西的三家抗凝诊所招募了经计算的315名患者样本。估计了一个包含与华法林剂量显著相关变量的模型。患者的平均年龄为64.1±13.1岁，其中173名（54.9%）为女性。年龄、胺碘酮的使用、基因GA基因型、基因AA基因型、基因或基因型以及基因或或基因型与华法林剂量降低有关。本研究指出了可能影响口服抗凝治疗管理的因素。
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