Carle Illinois College of Medicine, University of Illinois, Urbana-Champaign, Urbana.
Department of Dermatology, Rush University Medical Center, Chicago.
Br J Dermatol. 2023 Dec 20;190(1):137-138. doi: 10.1093/bjd/ljad324.
The use of dupilumab has been suggested in the treatment of immune checkpoint inhibitor (ICI)-induced bullous pemphigoid. In this letter, we express caution with the targeted inhibition of the Th2 pathway given current evidence suggesting the beneficial effect of the Th2 response, particularly eosinophilia, to ICI responses, particularly in melanoma.
已有研究表明,度普利尤单抗(dupilumab)可用于治疗免疫检查点抑制剂(ICI)诱导的大疱性类天疱疮。在这封信中,鉴于目前的证据表明 Th2 反应(尤其是嗜酸性粒细胞增多症)对 ICI 反应(尤其是黑色素瘤)有益,我们对靶向抑制 Th2 通路持谨慎态度。