氟代脱氧葡萄糖正电子发射断层扫描在复发/难治性霍奇金淋巴瘤中的应用：一种实用方法。
Fluorodeoxyglucose-Positron Emission Tomography in Relapsed/Refractory Hodgkin Lymphoma: A Practical Approach.
机构信息
Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Department of Medicine and Surgery, Research Unit of Hematology, Università Campus Bio-Medico, Rome, Italy.
出版信息
Chemotherapy. 2024;69(1):1-10. doi: 10.1159/000533766. Epub 2023 Sep 14.
BACKGROUND
Positron emission tomography (PET) with the use of 18F-fluorodeoxyglucose (FDG), implemented with low-dosage computer tomography, is to be considered as the most important evolution of imaging in the management and assessment of classical Hodgkin lymphoma patients.
SUMMARY
According to Lugano response criteria, FDG-PET is mandatory to define metabolic response to frontline therapy and moreover it is important in the definition of nonresponders or refractory disease patients. Refractory disease is reported in about 15% of patients, with some variations based on the choice of first-line chemotherapy, and particularly in advanced stages, up to 40% eventually relapse within 3 years.
KEY MESSAGES
The aim of this review was to highlight a practical way to use FDG-PET in the subset of HL, with some notes of its use in first-line patients, and particularly centered on relapsed or refractory setting with a final focus of the evaluation of response by FDG-PET in the new treatment era of immunocheckpoint inhibitors.
背景
使用 18F-氟脱氧葡萄糖（FDG）的正电子发射断层扫描（PET）与低剂量计算机断层扫描相结合，被认为是经典霍奇金淋巴瘤患者管理和评估中影像学最重要的进展。
摘要
根据 Lugano 缓解标准，FDG-PET 是定义一线治疗代谢反应的强制性手段，而且对于定义无应答者或难治性疾病患者也很重要。难治性疾病在约 15%的患者中报告，具体取决于一线化疗的选择，特别是在晚期，约 40%的患者最终在 3 年内复发。
关键信息
本综述旨在强调在霍奇金淋巴瘤亚组中使用 FDG-PET 的一种实用方法，同时还介绍了其在一线患者中的一些应用，特别是集中在复发或难治性患者中，并最终聚焦于免疫检查点抑制剂新治疗时代 FDG-PET 对缓解的评估。
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