State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Frontiers Science Center for Materiobiology and Dynamic Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Macromol Biosci. 2024 Feb;24(2):e2300327. doi: 10.1002/mabi.202300327. Epub 2023 Sep 25.
The infections associated with implantable medical devices can greatly affect the therapeutic effect and impose a heavy financial burden. Therefore, it is of great significance to develop antimicrobial biomaterials for the prevention and mitigation of healthcare-associated infections. Here, a facile construction of antimicrobial surface via one-step co-deposition of peptide polymer and dopamine is reported. The co-deposition of antimicrobial peptide polymer DLL BLG with dopamine (DA) on the surface of thermoplastic polyurethane (TPU) provides peptide polymer-modified TPU surface (TPU-DLL BLG ). The antimicrobial test shows that the TPU-DLL BLG surfaces of the sheet and the catheter both exhibit potent killing of 99.9% of methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). In addition, the TPU-DLL BLG surface also exhibits excellent biocompatibility. This one-step antimicrobial modification method is fast and efficient, implies promising application in surface antimicrobial modification of implantable biomaterials and medical devices.
植入式医疗器械相关感染会极大地影响治疗效果，并造成沉重的经济负担。因此，开发用于预防和减轻与医疗保健相关感染的抗菌生物材料具有重要意义。在这里，报道了一种通过一步共沉积肽聚合物和多巴胺来构建抗菌表面的简便方法。抗菌肽聚合物 DLL BLG 与多巴胺（DA）在热塑性聚氨酯（TPU）表面的共沉积为肽聚合物改性 TPU 表面（TPU-DLL BLG）。抗菌试验表明，片材和导管的 TPU-DLL BLG 表面均能有效杀灭 99.9%的耐甲氧西林金黄色葡萄球菌（MRSA）和大肠杆菌（E. coli）。此外，TPU-DLL BLG 表面还表现出优异的生物相容性。这种一步法抗菌改性方法快速高效，有望应用于植入式生物材料和医疗器械的表面抗菌改性。
Zotero 插件