Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.
Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
Eur J Nucl Med Mol Imaging. 2023 Dec;51(1):196-201. doi: 10.1007/s00259-023-06439-2. Epub 2023 Sep 16.
Intracytoplasmic melanin pigment is a characteristic of clear cell sarcoma (CCS), which is a particularly deadly type of soft-tissue sarcoma. [F]-N-(2-(diethylamino)ethyl)-5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)picolinamide ([F]-PFPN) is a positron emission tomography (PET) probe characterized by high melanin affinity. Therefore, this study aimed to investigate the feasibility of melanin-targeted [F]-PFPN PET in patients with CCS.
This prospective single-centre study recruited patients with pathologically confirmed CCS. [F]-FDG PET/computed tomography and [F]-PFPN PET/magnetic resonance imaging scans were performed within 1 week of each other. The lesion numbers and [F]-FDG and [F]-PFPN PET parameters (maximum standardized uptake value [SUVmax], mean standardized uptake value [SUVmean], metabolic/melanotic tumour volume [MTV/MLTV], and total lesion glycolysis/melanin [TLG/TLM]) were collected.
Three patients with CCS were recruited and received PET imaging. A total of 56 lesions were detected on [F]-PFPN PET, including primary tumour and distant metastases. Identical lesions were not detected on [F]-PFPN and [F]-FDG PET. Twelve lesions (12/39, 30.77%) on [F]-FDG imaging were missed on [F]-PFPN, and 20 lesions (20/47, 42.55%) on [F]-PFPN imaging were missed on [F]-FDG. In quantitative analysis, the [F]-FDG SUVmean (4.60 ± 3.24) was higher than the [F]-PFPN SUVmean (3.0 ± 2.63) in all lesions (P = 0.01). No significant correlations were found between the SUVmax, SUVmean, MLTV/MTV, and TLM/TLG values of [F]-PFPN and [F]-FDG (P > 0.05).
Melanin-targeted [F]-PFPN PET imaging is feasible for the diagnosis of CCS. Different imaging features were displayed on [F]-PFPN and [F]-FDG PET imaging, demonstrating the complementary role of the tracers. Combined use of the two imaging modalities would be preferred in patients with CCS.
NCT05963035.
细胞质内黑色素是透明细胞肉瘤(CCS)的特征,CCS 是一种特别致命的软组织肉瘤。[F]-N-(2-(二乙氨基)乙基)-5-(2-(2-(2-氟乙氧基)乙氧基)乙氧基)吡啶酰胺([F]-PFPN) 是一种正电子发射断层扫描(PET)探针,具有高黑色素亲和力。因此,本研究旨在探讨黑色素靶向[F]-PFPN PET 在 CCS 患者中的可行性。
这项前瞻性单中心研究招募了经病理证实的 CCS 患者。在彼此相隔 1 周内进行[F]-FDG PET/CT 和[F]-PFPN PET/磁共振成像扫描。收集了病变数量和[F]-FDG 和[F]-PFPN PET 参数(最大标准化摄取值[SUVmax]、平均标准化摄取值[SUVmean]、代谢/黑色素瘤体积[MTV/MLTV]和总病变糖酵解/黑色素[TLG/TLM])。
3 名 CCS 患者接受了 PET 成像。在[F]-PFPN PET 上共检测到 56 个病变,包括原发肿瘤和远处转移。在[F]-FDG 和[F]-PFPN PET 上未发现相同的病变。在[F]-FDG 成像上,12 个病变(12/39,30.77%)漏诊,在[F]-PFPN 成像上,20 个病变(20/47,42.55%)漏诊。在定量分析中,所有病变的[F]-FDG SUVmean(4.60±3.24)均高于[F]-PFPN SUVmean(3.0±2.63)(P=0.01)。[F]-PFPN 的 SUVmax、SUVmean、MLTV/MTV 和 TLM/TLG 值与[F]-FDG 之间无显著相关性(P>0.05)。
黑色素靶向[F]-PFPN PET 成像对 CCS 的诊断是可行的。[F]-PFPN 和[F]-FDG PET 成像显示出不同的成像特征,表明示踪剂具有互补作用。CCS 患者应首选两种成像方式联合使用。
NCT05963035。