CREG在代谢紊乱中的一种新功能。

A novel function of CREG in metabolic disorders.

作者信息

Li Yang, Tian Xiaoxiang, Zhang Quanyu, Yan Chenghui, Han Yaling

机构信息

Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang 110016, Liaoning, China.

出版信息

Med Rev (2021). 2022 Jan 11;1(1):18-22. doi: 10.1515/mr-2021-0031. eCollection 2021 Oct.

DOI:10.1515/mr-2021-0031

PMID:37724076

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10388757/

Abstract

Metabolic disorders are public health problems that require prevention and new efficient drugs for treatment. Cellular repressor of E1A-stimulated genes (CREG) is ubiquitously expressed in mature tissues and cells in mammals and plays a critical role in keeping cells or tissues in a mature, homeostatic state. Recently, CREG turns to be an important mediator in the development of metabolic disorders. Here in this review, we briefly discuss the structure and molecular regulation of CREG along with the therapeutic strategy to combat the metabolic disorders.

摘要

代谢紊乱是需要预防和新型高效治疗药物的公共卫生问题。E1A 刺激基因的细胞抑制因子（CREG）在哺乳动物的成熟组织和细胞中普遍表达，并在维持细胞或组织处于成熟的稳态中发挥关键作用。最近，CREG 已成为代谢紊乱发展过程中的一个重要介质。在本综述中，我们简要讨论了 CREG 的结构和分子调控以及对抗代谢紊乱的治疗策略。