Ault B, Gruenthal M, Armstrong D R, Nadler J V
J Pharmacol Exp Ther. 1986 Nov;239(2):612-7.
Baclofen and phenobarbital were tested for anticonvulsant efficacy against limbic seizures produced by i.c.v. infusion of kainic acid (KA) in unanesthetized rats. All rats treated with KA alone developed a prolonged status epilepticus associated with extensive neuronal degeneration. When administered immediately after the KA infusion, baclofen (5 mg/kg i.p.) protected five of six animals against the development of status epilepticus and did not alter the behavioral expression of the residual discrete electrographic seizures. Phenobarbital (40 mg/kg i.p.) given 15 min before KA also prevented the development of status epilepticus in five of six rats, but blocked the behavioral expression of the residual electrographic seizures. In two of five additional rats, baclofen prevented or reversed status epilepticus when administered 50 to 60 min after the end of the KA infusion. The ability of these drugs to prevent KA-induced neuronal degeneration correlated with their anticonvulsant action.
在未麻醉的大鼠中，测试了巴氯芬和苯巴比妥对脑室内注射 kainic 酸（KA）诱发的边缘叶癫痫发作的抗惊厥疗效。所有单独接受 KA 治疗的大鼠均出现了与广泛神经元变性相关的长时间癫痫持续状态。在 KA 注射后立即给药时，巴氯芬（腹腔注射 5 mg/kg）保护了六只动物中的五只免受癫痫持续状态的发展，并且没有改变残余离散脑电图癫痫发作的行为表现。在 KA 注射前 15 分钟给予苯巴比妥（腹腔注射 40 mg/kg）也预防了六只大鼠中五只的癫痫持续状态发展，但阻断了残余脑电图癫痫发作的行为表现。在另外五只大鼠中的两只中，巴氯芬在 KA 注射结束后 50 至 60 分钟给药时预防或逆转了癫痫持续状态。这些药物预防 KA 诱导的神经元变性的能力与其抗惊厥作用相关。
