Schwark W S, Frey H H, Czuczwar S J
Neuropharmacology. 1986 Aug;25(8):839-44. doi: 10.1016/0028-3908(86)90008-0.
The effect on the parameters of seizures of opiates, administered in doses used clinically for analgesic effects, was studied in rats with full amygdaloid-kindled seizures. The largest dose of fentanyl studied (100 micrograms/kg) had a pronounced inhibitory effect on kindled seizures: severity of seizures, duration of seizures and duration of afterdischarge were significantly reduced to 36, 40 and 37% of controls, respectively, and the latency of seizures was significantly increased to 168% of untreated animals. The largest dose of pentazocine (16 mg/kg) also significantly inhibited the duration of seizures and duration of afterdischarge. Morphine (1-4 mg/kg) and meperidine (4-16 mg/kg) had a tendency to inhibit the duration of seizure and afterdischarges but did not significantly affect any of the measured parameters of seizures. Fentanyl, meperidine and pentazocine resulted in a lowering, whereas morphine caused a slight elevation, of the threshold for initiation of kindled seizures. The data suggest that fentanyl, in relatively small doses, may cause an inhibition of the intensity of behavioural and electrographic seizures but, paradoxically, an increased sensitivity to induction of seizures in rats with full amygdaloid-kindled seizures.
在患有完全杏仁核点燃性癫痫发作的大鼠中，研究了临床用于镇痛的剂量的阿片类药物对癫痫发作参数的影响。所研究的芬太尼最大剂量（100微克/千克）对点燃性癫痫发作有显著抑制作用：癫痫发作的严重程度、发作持续时间和放电后持续时间分别显著降低至对照组的36%、40%和37%，癫痫发作潜伏期显著增加至未治疗动物的168%。喷他佐辛最大剂量（16毫克/千克）也显著抑制了癫痫发作持续时间和放电后持续时间。吗啡（1 - 4毫克/千克）和哌替啶（4 - 16毫克/千克）有抑制癫痫发作持续时间和放电后持续时间的趋势，但对任何测量的癫痫发作参数均无显著影响。芬太尼、哌替啶和喷他佐辛导致点燃性癫痫发作起始阈值降低，而吗啡则导致其略有升高。数据表明，相对小剂量的芬太尼可能会抑制行为性和脑电图癫痫发作的强度，但矛盾的是，会增加患有完全杏仁核点燃性癫痫发作的大鼠对癫痫发作诱导的敏感性。
