Department of Cardiovascular Diseases, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA.
Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, 10701 East Blvd, Cleveland, OH 44106, USA.
Cardiol Clin. 2023 Nov;41(4):537-544. doi: 10.1016/j.ccl.2023.06.010. Epub 2023 Jul 24.
Obesity has been long recognized as a risk factor for the development of heart failure, but recent evidence suggests obesity is more typically associated with heart failure with preserved ejection fraction as opposed to heart failure with reduced ejection fraction (HFrEF). Nevertheless, numerous studies have found that obesity modulates the presentation and progression of HFrEF and may contribute to the development of HFrEF in some patients. Although obesity has definite negative effects in HFrEF patients, the effects of intentional weight loss in HFrEF patients with obesity have been poorly studied.
肥胖症长期以来一直被认为是心力衰竭发展的一个风险因素，但最近的证据表明，肥胖症与射血分数保留型心力衰竭（HFpEF）的关系更为密切，而不是射血分数降低型心力衰竭（HFrEF）。尽管如此，许多研究发现肥胖症会影响 HFrEF 的表现和进展，并可能导致某些患者发生 HFrEF。虽然肥胖症对 HFrEF 患者有明确的负面影响，但肥胖症 HFrEF 患者的体重管理效果研究还不够充分。
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