Bai Yang, Zhao Feng, Wu Tingting, Chen Fangchun, Pang Xiaoxiao
Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.
Front Physiol. 2023 Sep 8;14:1213668. doi: 10.3389/fphys.2023.1213668. eCollection 2023.
Development is a complex process that occurs throughout the life cycle. F-actin, a major component of the cytoskeleton, is essential for the morphogenesis of tissues and organs during development. F-actin is formed by the polymerization of G-actin, and the dynamic balance of polymerization and depolymerization ensures proper cellular function. Disruption of this balance results in various abnormalities and defects or even embryonic lethality. Here, we reviewed recent findings on the structure of G-actin and F-actin and the polymerization of G-actin to F-actin. We also focused on the functions of actin isoforms and the underlying mechanisms of actin polymerization/depolymerization in cellular and organic morphogenesis during development. This information will extend our understanding of the role of actin polymerization in the physiologic or pathologic processes during development and may open new avenues for developing therapeutics for embryonic developmental abnormalities or tissue regeneration.
发育是一个贯穿生命周期的复杂过程。F-肌动蛋白是细胞骨架的主要成分，对发育过程中组织和器官的形态发生至关重要。F-肌动蛋白由G-肌动蛋白聚合而成，聚合和解聚的动态平衡确保细胞功能正常。这种平衡的破坏会导致各种异常和缺陷，甚至胚胎致死。在此，我们综述了关于G-肌动蛋白和F-肌动蛋白结构以及G-肌动蛋白向F-肌动蛋白聚合的最新研究结果。我们还重点关注了肌动蛋白异构体的功能以及发育过程中细胞和器官形态发生中肌动蛋白聚合/解聚的潜在机制。这些信息将扩展我们对肌动蛋白聚合在发育过程中的生理或病理过程中作用的理解，并可能为开发针对胚胎发育异常或组织再生的治疗方法开辟新途径。
