Gulliver Chloe, Baillie George S, Hoffmann Ralf
School of Cardiovascular & Metabolic Health, College of Medical, Veterinary & Life Science, University of Glasgow, Glasgow, G12 8QQ, U.K.
Philips Research Europe, High Tech Campus, Eindhoven, 5656AE, The Netherlands.
Future Sci OA. 2023 Jul 29;9(9):FSO888. doi: 10.2144/fsoa-2023-0064. eCollection 2023 Oct.
expression is significantly associated with prostate cancer (PCa) progression, representing an attractive prognostic biomarker. We sought to determine whether other genes in the coding region were associated.
PATIENTS & METHODS: RNA from biopsy punch samples of resected tumor tissue was analyzed via RNA sequencing. RT-qPCR was used to determine score.
Numerous genomic sequences within the coding region on Chr5q12 revealed similar mRNA expression profiles to . had a significantly similar expression pattern to across samples, correlating with disease progression. However, many other genes also exhibited matched expression to , including miRNAs and lncRNAs.
These novel -associated genes, many of which are previously uncharacterized in cancer, represent putative PCa biomarkers and could have mechanistic roles in PCa progression.
[基因名称]的表达与前列腺癌（PCa）进展显著相关，是一种有吸引力的预后生物标志物。我们试图确定编码区的其他基因是否相关。
通过RNA测序分析来自切除肿瘤组织活检穿刺样本的RNA。使用RT-qPCR确定[基因名称]评分。
5号染色体q12区域编码区内的众多基因组序列显示出与[基因名称]相似的mRNA表达谱。在各样本中，[另一基因名称]与[基因名称]具有显著相似的表达模式，与疾病进展相关。然而，许多其他基因也表现出与[基因名称]匹配的表达，包括miRNA和lncRNA。
这些新的[基因名称]相关基因，其中许多在癌症中以前未被表征，代表了假定的PCa生物标志物，并且可能在PCa进展中具有机制性作用。
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