孟加拉国HIV-1非C亚型的高度多样性及传播动态

High Diversity and Transmission Dynamics of HIV-1 Non-C Subtypes in Bangladesh.

作者信息

Sarker Md Safiullah, Jahan Rubiyat

机构信息

Virology Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.

School of Business and Economics, North South University, Dhaka 1229, Bangladesh.

出版信息

Trop Med Infect Dis. 2023 Sep 17;8(9):451. doi: 10.3390/tropicalmed8090451.

DOI:10.3390/tropicalmed8090451

PMID:37755912

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10535170/

Abstract

Genetic diversity and molecular epidemiology of HIV are directly relevant to HIV transmission. We report here the genetic diversity and transmission dynamics of non-C subtypes of HIV-1 strains detected in Bangladeshi key populations. Sequence analysis of gene revealed four subtypes A1, B, D, G, and nine CRFs (01_AE, 02_AG, 09_cpx, 10_CD, 15_AE/B, 13_cpx, 14_BG, 22_01_A1, and 25_AGU). Most of these non-C strains were detected in returnee migrant workers from different parts of the world. Phylogenetic analysis showed that the Bangladeshi HIV-1 strains detected in migrant workers and their wives and local sex workers shared common ancestries. The identification of the multiple subtypes indicates high diversity of non-C HIV-1 variants circulating in Bangladesh which might have been imported by migrant workers from multiple geographical areas.

摘要

HIV的遗传多样性和分子流行病学与HIV传播直接相关。我们在此报告在孟加拉国重点人群中检测到的HIV-1毒株非C亚型的遗传多样性和传播动态。对基因的序列分析揭示了四种亚型A1、B、D、G以及九种CRF（01_AE、02_AG、09_cpx、10_CD、15_AE/B、13_cpx、14_BG、22_01_A1和25_AGU）。这些非C毒株大多在来自世界不同地区的归国农民工中检测到。系统发育分析表明，在农民工及其妻子和当地性工作者中检测到的孟加拉国HIV-1毒株具有共同的祖先。多种亚型的鉴定表明，在孟加拉国流行的非C HIV-1变体具有高度多样性，这些变体可能是由农民工从多个地理区域引入的。