Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, No 2, Section 5, Renmin Street, Jinzhou, 121099, China.
School of Nursing, Jinzhou Medical University, Jinzhou, 121099, China.
Inflammopharmacology. 2024 Apr;32(2):1461-1474. doi: 10.1007/s10787-023-01320-y. Epub 2023 Sep 27.
Lately, interest surrounding the utilization of plant-derived compounds as a viable beneficial approach for treating Alzheimer's disease (AD) has significantly increased. This study aimed to assess the defensive properties of rosavin against Alzheimer's disease induced by amyloid-β, utilizing experimental models. We found that rosavin exhibited anti-aggregation and disaggregation properties, suggesting its potential to prevent the gathering of Aβ-aggregates. In vitro experiments revealed that rosavin effectively mitigated the neurotoxicity induced by Aβ in Neuro-2a cells, showcasing its protective potential. Rosavin significantly improved the Aβ-induced cognitive deficits in Wistar rats, particularly in spatial memory. Which the pathophysiology of AD includes oxidative damage, which negatively impacts biological macromolecules. Triggers the apoptotic process, causing macromolecular destruction. Interestingly, rosavin attenuated Aβ-induced macromolecular damages, thereby preserving neuronal integrity. Furthermore, the activation of antioxidative defense enzymes by rosavin inhibited oxidative damage. The positive outcomes associated with rosavin were primarily attributed to its capacity to enhance acetylcholine-mediated effects. Finally, rosavin has the potential to alleviate Aβ-induced neurotoxicity and macromolecular damages, ultimately resulting in enhanced memorial and reasoning function in Wistar rats, offering promising prospects for the treatment of AD.
最近，人们对利用植物衍生化合物作为治疗阿尔茨海默病 (AD) 的可行有益方法的兴趣显著增加。本研究旨在利用实验模型评估瑞沙醇对淀粉样蛋白-β诱导的 AD 的防御特性。我们发现瑞沙醇具有抗聚集和去聚集特性，表明其具有预防 Aβ聚集的潜力。体外实验表明，瑞沙醇能有效减轻 Aβ在Neuro-2a 细胞中诱导的神经毒性，显示其保护潜力。瑞沙醇能显著改善 Wistar 大鼠 Aβ诱导的认知功能障碍，特别是在空间记忆方面。AD 的发病机制包括氧化损伤，它会对生物大分子造成负面影响。触发凋亡过程，导致大分子破坏。有趣的是，瑞沙醇减轻了 Aβ诱导的大分子损伤，从而保护了神经元的完整性。此外，瑞沙醇激活抗氧化防御酶抑制氧化损伤。瑞沙醇的积极作用主要归因于其增强乙酰胆碱介导作用的能力。最后，瑞沙醇有可能减轻 Aβ诱导的神经毒性和大分子损伤，最终提高 Wistar 大鼠的记忆和推理功能，为 AD 的治疗提供了有希望的前景。
