College of Environment and Ecology, Hunan Agricultural University, Changsha, 410128, China.
CAS Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.
Biol Trace Elem Res. 2024 Jun;202(6):2588-2597. doi: 10.1007/s12011-023-03874-y. Epub 2023 Sep 27.
Iron plays a key role in maternal health during pregnancy and fetal growth. Enteromorpha polysaccharide-iron (EP-Fe) as an organic iron chelate may improve the iron transmission of mother and offspring, ameliorate the poor pregnancy outcomes of sows, and alleviate the growth restriction of piglets caused by iron deficiency. This study aimed to evaluate the effects of maternal dietary supplementation with EP-Fe on reproductive performance and placental iron transmission of sows, as well as growth performance of piglets. Sixty pregnant sows at the 95th day of gestation were randomly divided into control group and EP-Fe group (EP-Fe, 139 mg kg). Blood samples of sows and neonatal piglets, colostrum, and tissue samples were collected on the day of delivery. The animal experiment ended at the 21st day of post-delivery. Results showed that maternal dietary EP-Fe increased colostrum iron (P < 0.05) of sows, as well as final litter weight (P < 0.05) and average daily weight of piglets (P < 0.05) during days 1-21 of lactation, as well as iron and manganese content in umbilical cord blood (P < 0.05) and hepatic iron of neonatal piglets (P < 0.01), and decreased fecal iron (P < 0.001), serum calcium (P < 0.05), phosphorus (P < 0.05), and zinc (P < 0.01) in the parturient sow. RT-qPCR results showed that Fpn1 and Zip14 in placenta, as well as TfR1 and Zip14 in duodenum of neonatal piglets, were activated by maternal EP-Fe supplement. These findings suggest that maternal dietary EP-Fe could increase iron storage of neonatal piglets via improving placental iron transport and iron secretion in colostrum, thus enhancing the growth performance of sucking piglets.
铁在妊娠期间的母婴健康和胎儿生长中起着关键作用。浒苔多糖-铁（EP-Fe）作为一种有机铁螯合物，可能改善母婴铁的传递，改善母猪妊娠结局不良，并缓解缺铁引起的仔猪生长受限。本研究旨在评估母体膳食补充 EP-Fe 对母猪繁殖性能和胎盘铁传递以及仔猪生长性能的影响。将 60 头妊娠第 95 天的母猪随机分为对照组和 EP-Fe 组（EP-Fe，139mg/kg）。分娩当天采集母猪和新生仔猪的血液样本、初乳和组织样本。动物实验于产后第 21 天结束。结果表明，母体膳食 EP-Fe 增加了母猪初乳铁（P<0.05），以及哺乳期第 1-21 天的仔猪总产仔数（P<0.05）和平均日增重（P<0.05），以及脐带血铁和锰含量（P<0.05）和新生仔猪肝脏铁含量（P<0.01），并降低了粪便铁（P<0.001）、产后母猪血清钙（P<0.05）、磷（P<0.05）和锌（P<0.01）。RT-qPCR 结果表明，母体 EP-Fe 补充激活了胎盘的 Fpn1 和 Zip14 以及新生仔猪十二指肠的 TfR1 和 Zip14。这些发现表明，母体膳食 EP-Fe 可以通过改善胎盘铁转运和初乳中铁的分泌来增加新生仔猪的铁储存，从而提高哺乳仔猪的生长性能。
