Allameh Abdolamir, Niayesh-Mehr Reyhaneh, Aliarab Azadeh, Sebastiani Giada, Pantopoulos Kostas
Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 1411713116, Iran.
Chronic Viral Illness Services, McGill University Health Center, Montreal, QC H4A 3J1, Canada.
Antioxidants (Basel). 2023 Aug 22;12(9):1653. doi: 10.3390/antiox12091653.
The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which not only arise during metabolic functions but also during the biotransformation of xenobiotics. The disruption of redox balance causes oxidative stress, which affects liver function, modulates inflammatory pathways and contributes to disease. Thus, oxidative stress is implicated in acute liver injury and in the pathogenesis of prevalent infectious or metabolic chronic liver diseases such as viral hepatitis B or C, alcoholic fatty liver disease, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Moreover, oxidative stress plays a crucial role in liver disease progression to liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Herein, we provide an overview on the effects of oxidative stress on liver pathophysiology and the mechanisms by which oxidative stress promotes liver disease.
肝脏是一个特别容易受到活性氧（ROS）影响的器官，ROS不仅在代谢功能过程中产生，在外源生物的生物转化过程中也会产生。氧化还原平衡的破坏会导致氧化应激，这会影响肝功能，调节炎症途径并导致疾病。因此，氧化应激与急性肝损伤以及诸如乙型或丙型病毒性肝炎、酒精性脂肪性肝病、非酒精性脂肪性肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）等常见感染性或代谢性慢性肝病的发病机制有关。此外，氧化应激在肝病进展为肝纤维化、肝硬化和肝细胞癌（HCC）的过程中起着至关重要的作用。在此，我们概述了氧化应激对肝脏病理生理学的影响以及氧化应激促进肝病的机制。
