Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy Grande Ospedale Metropolitano "Bianchi-Malacrino-Morelli", 89124 Reggio Calabria, Italy.
Hematology Unit, Department of Hemato-Oncology and Radiotherapy Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", 89124 Reggio Calabria, Italy.
Genes (Basel). 2023 Sep 13;14(9):1796. doi: 10.3390/genes14091796.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a clinically challenging modality for the treatment of many hematologic diseases such as leukemia, lymphoma, and myeloma. Graft-versus-host disease (GVHD) is a common complication after allo-HSCT and remains a major cause of morbidity and mortality, limiting the success of a potentially curative transplant. Several microRNAs (miRNAs) have recently been shown to impact the biology of GVHD. They are molecular regulators involved in numerous processes during T-cell development, homeostasis, and activation, and contribute to the pathological function of T-cells during GvHD. Here, we review the key role of miRNAs contributing to the GvHD; their detection might be an interesting possibility in the early diagnosis and monitoring of disease.
异基因造血干细胞移植（allo-HSCT）是治疗白血病、淋巴瘤和骨髓瘤等许多血液疾病的一种具有挑战性的临床方法。移植物抗宿主病（GVHD）是 allo-HSCT 后的常见并发症，仍是发病率和死亡率的主要原因，限制了潜在治愈性移植的成功。最近已经证明，几种 microRNAs（miRNAs）会影响 GVHD 的生物学特性。miRNAs 是 T 细胞发育、稳态和激活过程中涉及的众多分子调节剂，并有助于 GvHD 期间 T 细胞的病理功能。在这里，我们回顾了 miRNAs 在 GvHD 中的关键作用；它们的检测可能是疾病早期诊断和监测的一个有趣的可能性。
