Callejón-Leblic Belén, Sánchez Espirilla Saida, Gotera-Rivera Carolina, Santana Rafael, Díaz-Olivares Isabel, Marín José M, Macario Ciro Casanova, Cosio Borja García, Fuster Antonia, García Ingrid Solanes, de-Torres Juan P, Feu Collado Nuria, Cabrera Lopez Carlos, Amado Diago Carlos, Romero Plaza Amparo, Fraysse Luis Alejandro Padrón, Márquez Martín Eduardo, Marín Royo Margarita, Balcells Vilarnau Eva, Llunell Casanovas Antonia, Martínez González Cristina, Galdíz Iturri Juan Bautista, Lacárcel Bautista Celia, Gómez-Ariza José Luis, Pereira-Vega Antonio, Seijo Luis, López-Campos José Luis, Peces-Barba Germán, García-Barrera Tamara
Department of Chemistry, Research Center for Natural Resources, Health and the Environment (RENSMA), Faculty of Experimental Sciences, University of Huelva, Campus El Carmen, Fuerzas Armadas Ave., 21007 Huelva, Spain.
Department of Chemistry, Faculty of Sciences, National University of San Antonio Abad of Cusco, Av. de La Cultura, Cusco 773, Peru.
Int J Mol Sci. 2023 Sep 18;24(18):14250. doi: 10.3390/ijms241814250.
Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.
肺癌（LC）是癌症死亡的主要原因，而慢性阻塞性肺疾病（COPD）会增加患肺癌的风险。金属组学可能为这两种与烟草相关的疾病及其共同病因提供见解。我们对191份人类血清样本进行了一项观察性研究，这些样本包括健康对照者、肺癌患者、慢性阻塞性肺疾病患者以及同时患有慢性阻塞性肺疾病和肺癌的患者。我们在这些样本中发现了18种元素（钒、铝、砷、锰、钴、铜、锌、镉、硒、钨、钼、锑、铅、铊、铬、镁、镍和铀）。此外，我们评估了不同严重程度的慢性阻塞性肺疾病病例的元素谱。还研究了元素之间的比例和关联，将其作为疾病的可能特征。慢性阻塞性肺疾病的严重程度和肺癌对人类血清的元素组成有显著影响。与健康对照样本相比，发现慢性阻塞性肺疾病的严重程度会降低血清中砷、镉和铊的浓度，并增加血清中锰和锑的浓度，而肺癌则会增加铝、砷、锰和铅的浓度。这项研究为肺癌和慢性阻塞性肺疾病对人类血清元素谱的影响提供了新的见解，这将为将元素用作诊断和预后生物标志物的潜在应用铺平道路。它还揭示了这两种疾病之间的潜在联系，即慢性阻塞性肺疾病向肺癌的演变。
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