Păun Monica, Torres Gustavo, Țiplica George Sorin, Cauni Victor Mihail
Dermatology Research Unit, Colentina Clinical Hospital, 020125 Bucharest, Romania.
Department of Dermatology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Medicina (Kaunas). 2023 Sep 13;59(9):1654. doi: 10.3390/medicina59091654.
: Androgenetic alopecia (AGA) and alopecia areata (AA) are the most common types of non-cicatricial alopecia. Both diseases have limited effective therapeutic options and affect patient quality of life. Pharmacogenetic tests can help predict the most appropriate treatment option by evaluating the single nucleotide polymorphisms (SNPs) corresponding to genes related to alopecia. The objective of the study was to evaluate and compare selected SNPs and genes in AA and AGA patients from Romania and Brazil. : We performed a retrospective study regarding the associations between AA and AGA and 45 tag SNPs of 15 genes in 287 Romanian and 882 Brazilian patients. The DNA samples were collected from oral mucosa using a swab. The SNPs were determined by the qPCR technique. Each genetic test displays the subject's genotype of the selected gene and the prediction of a successful treatment (e.g., genotype AA of the GR-alpha gene is related to a predisposition to normal sensibility to topical glucocorticoid, and, therefore, glucocorticoids should be effective). : The , , , and genes were statistically significantly different in Brazil compared to Romania. The activity that predicts the response to minoxidil treatment showed in our analysis that minoxidil is recommended in half of the cases of AGA and AA. Patients with AGA and a high expression of or -2 may benefit from Dutasteride or Latanoprost treatment, respectively. Most of the studied genes showed no differences between the two populations. : The DNA analysis of the patients with alopecia may contribute to a successful treatment.
雄激素性脱发（AGA）和斑秃（AA）是最常见的非瘢痕性脱发类型。这两种疾病的有效治疗选择有限，并影响患者的生活质量。药物遗传学检测可通过评估与脱发相关基因对应的单核苷酸多态性（SNP），帮助预测最合适的治疗方案。本研究的目的是评估和比较罗马尼亚和巴西AA和AGA患者中选定的SNP和基因。：我们对287名罗马尼亚患者和882名巴西患者进行了一项关于AA和AGA与15个基因的45个标签SNP之间关联的回顾性研究。使用拭子从口腔黏膜收集DNA样本。通过qPCR技术确定SNP。每项基因检测显示所选基因的受试者基因型以及成功治疗的预测（例如，GR-α基因的AA基因型与局部糖皮质激素正常敏感性的易感性相关，因此，糖皮质激素应该有效）。：与罗马尼亚相比，巴西的、、和基因在统计学上有显著差异。预测米诺地尔治疗反应的活性在我们的分析中表明，在一半的AGA和AA病例中推荐使用米诺地尔。AGA且或-2高表达的患者可能分别从度他雄胺或拉坦前列素治疗中获益。大多数研究基因在这两个人群之间没有差异。：对脱发患者的DNA分析可能有助于成功治疗。
