生物活性导向的植物化学研究、两种越南药用植物的体外和计算机模拟α-葡萄糖苷酶抑制作用 以及 。 （原文最后“and.”表述不太完整规范，译文尽量忠实呈现原文内容）
Bioactive-Guided Phytochemical Investigations, In Vitro and In Silico Alpha-Glucosidase Inhibition of Two Vietnamese Medicinal Plants and .
作者信息
Duong Thuc-Huy, Vu Y Thien, Long Nguyen Phuoc, Phan Nguyen-Hong-Nhi, Pham Nguyen-Kim-Tuyen, Sichaem Jirapast, Kieu Nguyen-Khanh-Duy, Duong Chi-Bao, Nguyen Thanh-Trung, Dang Van-Son, Nguyen Huy Truong
机构信息
Department of Chemistry, University of Education, 280 An Duong Vuong Street, District 5, Ho Chi Minh City 700000, Vietnam.
Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam.
出版信息
Pharmaceuticals (Basel). 2023 Sep 5;16(9):1253. doi: 10.3390/ph16091253.
Little is known about the chemical and biological profiles of and . No previous studies have investigated alpha-glucosidase inhibition using extracts from and . In this paper, bioactive-guided isolation procedures were applied to the plants and based on alpha-glucosidase inhibition. From the most active fractions, 20 compounds (- and -) were isolated. The chemical structures were elucidated using spectroscopic data and compared with those available in the literature. These compounds were evaluated for alpha-glucosidase inhibition, while a molecular docking study was performed to elucidate the mechanisms involved. Consequently, and might serve as a good potential for developing new antidiabetic preparations.
关于[植物名称1]和[植物名称2]的化学和生物学特征知之甚少。以前没有研究使用[植物名称1]和[植物名称2]的提取物来研究α-葡萄糖苷酶抑制作用。在本文中，基于α-葡萄糖苷酶抑制作用，对[植物名称1]和[植物名称2]应用了生物活性导向分离程序。从活性最高的馏分中分离出20种化合物（[化合物名称1]和[化合物名称2]）。使用光谱数据阐明化学结构，并与文献中的结构进行比较。对这些化合物进行α-葡萄糖苷酶抑制作用评估，同时进行分子对接研究以阐明其中涉及的机制。因此，[植物名称1]和[植物名称2]可能具有开发新型抗糖尿病制剂的良好潜力。
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