Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom.
Nat Commun. 2023 Sep 30;14(1):6122. doi: 10.1038/s41467-023-41897-0.
Foraging behavior requires weighing costs of time to decide when to leave one reward patch to search for another. Computational and animal studies suggest that striatal dopamine is key to this process; however, the specific role of dopamine in foraging behavior in humans is not well characterized. We use positron emission tomography (PET) imaging to directly measure dopamine synthesis capacity and D and D receptor availability in 57 healthy adults who complete a computerized foraging task. Using voxelwise data and principal component analysis to identify patterns of variation across PET measures, we show that striatal D and D receptor availability and a pattern of mesolimbic and anterior cingulate cortex dopamine function are important for adjusting the threshold for leaving a patch to explore, with specific sensitivity to changes in travel time. These findings suggest a key role for dopamine in trading reward benefits against temporal costs to modulate behavioral adaptions to changes in the reward environment critical for foraging.
觅食行为需要权衡时间成本，以决定何时离开一个奖励斑块去寻找另一个。计算和动物研究表明纹状体多巴胺是这个过程的关键；然而，多巴胺在人类觅食行为中的具体作用还没有很好地描述。我们使用正电子发射断层扫描（PET）成像技术直接测量 57 名健康成年人的多巴胺合成能力和 D 和 D 受体可用性，这些成年人完成了一项计算机化的觅食任务。通过使用体素数据和主成分分析来识别 PET 测量结果的变化模式，我们表明纹状体 D 和 D 受体可用性以及中脑边缘和前扣带皮层多巴胺功能模式对于调整离开斑块进行探索的阈值很重要，对旅行时间的变化具有特定的敏感性。这些发现表明多巴胺在权衡奖励收益与时间成本以调节行为适应奖励环境变化方面起着关键作用，这对于觅食至关重要。
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