Tudor Adriana, Novac Liliana, Camen Ioana-Victoria, Manolea Maria Magdalena, Sandulescu Maria-Sidonia, Vrabie Sidonia Catalina, Serbanescu Mircea-Sebastian, Boldeanu Mihail Virgil, Istrate-Ofiteru Anca-Maria, Dijmarescu Anda Lorena
Doctoral School, University of Medicine and Pharmacology of Craiova, Romania.
Obstetrics and Gynecology Department, University of Medicine and Pharmacology of Craiova, Romania.
Curr Health Sci J. 2023 Apr-Jun;49(2):251-256. doi: 10.12865/CHSJ.49.02.251. Epub 2023 Jun 30.
Placenta-mediated pregnancy disorders represent a disease that includes preeclampsia (PE) and the birth of small for gestational age (SGA) children, these conditions increase the risk of mortality and morbidity both maternal and fetal/neonatal, in the short and long-term.
The prospective study included 106 patients in whom ultrasound Doppler scans of uterine artery (UtA) were performed in the 2nd trimester between 20.0-23.6 weeks of gestation and the 3rd trimester between 28.0-32.6 weeks of gestation.
In the second trimester, the average of the UtA-PI percentiles was statistically significant (p<0.05) in correlation with PE and SGA, as in the third trimester. Statistically significant (p<0.05) was also the correlation of UtA-PI >95 percentile with the development of PE and SGA. On the other hand, the present notch, in the two trimesters studied, analyzed as a single index, did not present a statistically significant association (p>0.05).
The results of our study showed that UtA-PI Doppler is the best predictor of preeclampsia considering the association of intrauterine growth restriction, as most studies have found.
胎盘介导的妊娠疾病是一种包括子痫前期(PE)和小于胎龄儿(SGA)出生的疾病,这些情况在短期和长期内都会增加孕产妇和胎儿/新生儿死亡和发病的风险。
这项前瞻性研究纳入了106例患者,在妊娠20.0 - 23.6周的孕中期和妊娠28.0 - 32.6周的孕晚期进行了子宫动脉(UtA)超声多普勒扫描。
在孕中期,UtA-PI百分位数的平均值与PE和SGA的相关性具有统计学意义(p<0.05),孕晚期也是如此。UtA-PI>95百分位数与PE和SGA的发生之间的相关性也具有统计学意义(p<0.05)。另一方面,在所研究的两个孕期中,作为单一指标分析的当前切迹并未呈现出统计学意义的关联(p>0.05)。
我们的研究结果表明,考虑到宫内生长受限的关联,UtA-PI多普勒是子痫前期的最佳预测指标,正如大多数研究所发现的那样。