肉桂（）热水提取物在体外和体内均可改善肠道炎症和紧密连接。
Cinnamon () hot water extract improves inflammation and tight junctions in the intestine in vitro and in vivo.
作者信息
Park Tae Gwon, Kim Yu Rim, Park Soo-Yeon, Choi Kwanyong, Kim Kyeong Jin, Kim Ji Yeon
机构信息
Department of Food Science and Technology, Seoul National University of Science and Technology, 232, Gongneung-Ro, Nowon-Gu, Seoul, 01811 Republic of Korea.
Department of Nano Bio Engineering, Seoul National University of Science and Technology, 232, Gongneung-Ro, Nowon-Gu, Seoul, 01811 Republic of Korea.
出版信息
Food Sci Biotechnol. 2023 Mar 27;32(13):1925-1933. doi: 10.1007/s10068-023-01292-3. eCollection 2023 Nov.
UNLABELLED
The natural byproduct was widely used in ancient Asia to cure disease because of its various pharmacological effects. Despite its ethnomedicinal benefits, few studies on the intestinal anti-inflammatory effect of have been reported. Therefore, this study aimed to evaluate the potential beneficial effects of on the intestine in vitro and in vivo. Herein, the effects of cinnamon hot water extract (CWE) on tight junction (TJ) barrier function, transepithelial electrical resistance, and mRNA expression were confirmed in Caco-2 cells. The CWE treatment groups showed significantly enhanced cell permeability, proinflammatory cytokine mRNA expression, and TJ expression. CWE-treated mice showed an improved histological index and decreased cytokine concentrations compared with those of colitis model mice. These results suggest that CWE alleviated inflammatory damage and improved the TJ barrier, indicating that CWE may be used as a functional food to improve intestinal health.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s10068-023-01292-3.
未标注
这种天然副产品在古代亚洲因具有多种药理作用而被广泛用于治疗疾病。尽管它有民族医药益处，但关于其肠道抗炎作用的研究报道很少。因此，本研究旨在评估其在体外和体内对肠道的潜在有益作用。在此，在Caco-2细胞中证实了肉桂热水提取物（CWE）对紧密连接（TJ）屏障功能、跨上皮电阻和mRNA表达的影响。CWE处理组的细胞通透性、促炎细胞因子mRNA表达和TJ表达显著增强。与结肠炎模型小鼠相比，CWE处理的小鼠组织学指标有所改善，细胞因子浓度降低。这些结果表明，CWE减轻了炎症损伤并改善了TJ屏障，表明CWE可作为一种功能性食品来改善肠道健康。
补充信息
在线版本包含可在10.1007/s10068-023-01292-3获取的补充材料。
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