钙离子（Ca2+）与佛波酯TPA对钾离子诱导牛肾上腺嗜铬细胞释放儿茶酚胺的协同作用。

Synergistic actions of Ca2+ and the phorbol ester TPA on K+-induced catecholamine release from bovine adrenal chromaffin cells.

作者信息

Brocklehurst K W, Pollard H B

出版信息

Biochem Biophys Res Commun. 1986 Nov 14;140(3):990-8. doi: 10.1016/0006-291x(86)90733-3.

DOI:10.1016/0006-291x(86)90733-3

Abstract

Enhancement of Ca2+-dependent high K+-evoked catecholamine secretion was observed after pretreatment of cultured bovine adrenal chromaffin cells with the phorbol ester 4B-phorbol 12-myristate 13-acetate (TPA) in the absence of added extracellular Ca2+. This effect of TPA was not reproduced when the secretagogues acetylcholine, nicotine, or veratrine were substituted for high K+. The implications of these results are discussed in relation to the role of protein kinase C in stimulus-secretion coupling in the chromaffin cell.

摘要

在无细胞外钙添加的情况下，用佛波酯4β-佛波醇12-肉豆蔻酸酯13-乙酸酯（TPA）预处理培养的牛肾上腺嗜铬细胞后，观察到钙依赖性高钾诱发的儿茶酚胺分泌增强。当用促分泌剂乙酰胆碱、尼古丁或藜芦碱替代高钾时，TPA的这种作用无法重现。结合蛋白激酶C在嗜铬细胞刺激-分泌偶联中的作用，讨论了这些结果的意义。

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