Orthopedic Dentistry Department, Medical Academy named after SI Georgievsky, VI Vernadsky Crimean Federal University, Simferopol, Russia.
Dentistry Department, Medical Academy named after SI Georgievsky, VI Vernadsky Crimean Federal University, Simferopol, Russia.
J Periodontal Res. 2023 Dec;58(6):1128-1138. doi: 10.1111/jre.13191. Epub 2023 Oct 3.
Periodontitis is one of the most common dental diseases with a range of treatment approaches, including pathogenetically reasonable use of various host immune modulators. One such approach is the use of omega-3 polyunsaturated fatty acids (PUFAs) in combination with low-dose aspirin. This systematic review and meta-analysis were performed to compare the standard treatment alone and adjunctive use of omega-3 PUFAs in combination with low-dose aspirin with or without standard treatment in patients with periodontitis. A systematic review of the literature was performed using MEDLINE/PubMed, Cochrane Central and Google Scholar databases. Selection criteria included the following: randomized controlled trials in subjects with periodontitis in the age group above 18 years old, with follow-up periods ranging from 6 weeks to 6 months. The meta-analysis was performed using standard methodological procedures according to Cochrane recommendations, including assessment of risk-of-bias and level of evidence (GRADE). Meta-analysis was performed for such clinical outcomes as plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment loss (CAL), bleeding on probing (BOP) and bleeding index (BI) based on data from seven randomized clinical trials conducted between 2010 and 2020. It was shown that adjunctive use of omega-3 PUFAs in combination with low-dose aspirin results in significant clinical improvement in PD, CAL and GI during both short and prolonged follow-up periods. The use of omega-3 PUFAs and low-dose aspirin in periodontitis patients may be promising as an adjunct therapy, however, due to a limited number of patients and significant heterogeneity, further studies need to be conducted.
牙周炎是最常见的牙科疾病之一，有多种治疗方法，包括合理应用各种宿主免疫调节剂。其中一种方法是联合小剂量阿司匹林使用ω-3 多不饱和脂肪酸（PUFAs）。本系统评价和荟萃分析旨在比较牙周炎患者单独使用标准治疗以及联合使用ω-3 PUFAs 联合小剂量阿司匹林与单独使用标准治疗的疗效。使用 MEDLINE/PubMed、Cochrane 中心和 Google Scholar 数据库进行文献系统评价。选择标准包括：年龄在 18 岁以上的牙周炎患者的随机对照试验，随访时间从 6 周到 6 个月不等。荟萃分析按照 Cochrane 建议的标准方法学程序进行，包括风险偏倚评估和证据水平（GRADE）。基于 2010 年至 2020 年期间进行的 7 项随机临床试验的数据，对菌斑指数（PI）、牙龈指数（GI）、探诊深度（PD）、临床附着丧失（CAL）、探诊出血（BOP）和出血指数（BI）等临床结局进行了荟萃分析。结果表明，联合使用ω-3 PUFAs 联合小剂量阿司匹林可在短时间和长时间随访期间显著改善 PD、CAL 和 GI。在牙周炎患者中使用ω-3 PUFAs 和小剂量阿司匹林可能作为一种辅助治疗方法有一定的前景，然而，由于患者数量有限且存在显著的异质性，需要进一步开展研究。
