Rager Julia E, Rider Cynthia V
The Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill.
The Institute for Environmental Health Solutions, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill.
Curr Opin Toxicol. 2023 Sep;35. doi: 10.1016/j.cotox.2023.100417.
Human health risk assessments for complex mixtures can address real-world exposures and protect public health. While risk assessors typically prefer whole mixture approaches over component-based approaches, data from the precise exposure of interest are often unavailable and surrogate data from a sufficiently similar mixture(s) are required. This review describes recent advances in determining sufficient similarity of whole, complex mixtures spanning the comparison of chemical features, bioactivity profiles, and statistical evaluation to determine "thresholds of similarity". Case studies, including water disinfection byproducts, botanical ingredients, and wildfire emissions, are used to highlight tools and methods. Limitations to application of sufficient similarity in risk-based decision making are reviewed and recommendations presented for developing best practice guidelines.
对复杂混合物进行人体健康风险评估能够应对实际暴露情况并保护公众健康。虽然风险评估人员通常更倾向于采用整体混合物方法而非基于成分的方法，但往往无法获得来自感兴趣的精确暴露的数据，因此需要来自足够相似混合物的替代数据。本综述描述了在确定整体复杂混合物的足够相似性方面的最新进展，涵盖化学特征比较、生物活性谱以及统计评估，以确定“相似性阈值”。通过案例研究，包括水消毒副产物、植物成分和野火排放，来突出相关工具和方法。文中回顾了在基于风险的决策中应用足够相似性的局限性，并提出了制定最佳实践指南的建议。
