Mayer Megan, Masoud Amgad
Department of Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA.
Cureus. 2023 Aug 31;15(8):e44463. doi: 10.7759/cureus.44463. eCollection 2023 Aug.
Few studies have explored the correlation between the severity of alcohol withdrawal and blood alcohol level at the time of admission. Specifying prognostic factors for life-threatening withdrawal necessitating inpatient pharmacologic management over the course of days would be useful to identify at-risk patients at the time of admission. Hence, we present the case of a 34-year-old Caucasian male with a past medical history of poly-substance abuse who has presented to our emergency department 11 times over the past four years with a mean blood alcohol level (BAL) of 287 mg/dL upon withdrawal. BAL at the time of withdrawal is highly variable depending on the chronicity of abuse; however, a BAL this elevated is highly unusual and indicative of severe and long-term use. While in the unit at this admission, the patient's BAL was 437 and his withdrawal symptoms were severe, necessitating ICU admission and strong sedating medications to control his symptoms. Even after these interventions, he still demonstrated severe withdrawal symptoms including full body tremors, vital sign instability, and continuous visual, auditory, and tactile hallucinations. This patient presents an interesting case of severe alcohol withdrawal at an abnormally elevated blood alcohol level progressing to a prolonged withdrawal course in the ICU. Alcohol level at the time of withdrawal could be a helpful predictor of the course of severity of alcohol withdrawal; however, more studies are required to prove this relationship.
很少有研究探讨酒精戒断的严重程度与入院时血液酒精水平之间的相关性。明确危及生命的戒断的预后因素,以便在数天的病程中确定需要住院药物治疗的情况,对于在入院时识别高危患者会很有帮助。因此,我们报告一例34岁的白种男性病例,其有多种物质滥用的既往病史,在过去四年中11次就诊于我们的急诊科,戒断时平均血液酒精水平(BAL)为287mg/dL。戒断时的BAL因滥用的慢性程度而有很大差异;然而,如此高的BAL非常罕见,表明存在严重且长期的饮酒情况。此次入院在病房期间,患者的BAL为437,其戒断症状严重,需要入住重症监护病房(ICU)并使用强效镇静药物来控制症状。即使经过这些干预措施,他仍表现出严重的戒断症状,包括全身震颤、生命体征不稳定以及持续的视幻觉、听幻觉和触幻觉。该患者呈现了一个有趣的病例,即血液酒精水平异常升高时出现严重酒精戒断,并在ICU中发展为长时间的戒断病程。戒断时的酒精水平可能有助于预测酒精戒断严重程度的病程;然而,需要更多研究来证实这种关系。