Martin Thomas G, Juarros Miranda A, Cleveland Joseph C, Bristow Michael R, Ambardekar Amrut V, Buttrick Peter M, Leinwand Leslie A
Department of Molecular, Cellular, and Developmental Biology and BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA.
Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
JACC Basic Transl Sci. 2023 Aug 23;8(9):1043-1056. doi: 10.1016/j.jacbts.2023.05.015. eCollection 2023 Sep.
Left ventricular reverse remodeling in heart failure is associated with improved clinical outcomes. However, the molecular features that drive this process are poorly defined. Left ventricular assist devices (LVADs) are the therapy associated with the greatest reverse remodeling and lead to partial myocardial recovery in most patients. In this study, we examined whether autophagy may be implicated in post-LVAD reverse remodeling. We found expression of key autophagy factors increased post-LVAD, while autophagic substrates decreased. Autolysosome numbers increased post-LVAD, further indicating increased autophagy. These findings support the conclusion that mechanical unloading activates autophagy, which may underly the reverse remodeling observed.
心力衰竭中的左心室逆向重构与临床结局改善相关。然而，驱动这一过程的分子特征尚不明确。左心室辅助装置（LVAD）是与最大程度逆向重构相关的治疗方法，并且在大多数患者中可导致部分心肌恢复。在本研究中，我们探究了自噬是否可能与LVAD植入后的逆向重构有关。我们发现关键自噬因子的表达在LVAD植入后增加，而自噬底物减少。自溶酶体数量在LVAD植入后增加，进一步表明自噬增强。这些发现支持了机械卸载激活自噬这一结论，而自噬可能是观察到的逆向重构的基础。
Zotero 插件
