Laboratory of Plant Molecular Virology, Department of Molecular and Evolutionary Plant Virology, Institute for Plant Molecular and Cell Biology, Consejo Superior de Investigaciones Científicas-Universitat Politècnica de València , Valencia, Spain.
J Virol. 2023 Oct 31;97(10):e0112423. doi: 10.1128/jvi.01124-23. Epub 2023 Oct 4.
Many plant proteins and some proteins from plant pathogens are dually targeted to chloroplasts and mitochondria, and are supposed to be transported along the general pathways for organellar protein import, but this issue has not been explored yet. Moreover, organellar translocon receptors exist as families of several members whose functional specialization in different cargos is supposed but not thoroughly studied. This article provides novel insights into such topics showing for the first time that an exogenous protein, the melon necrotic spot virus coat protein, exploits the common Toc/Tom import systems to enter both mitochondria and chloroplasts while identifying the involved specific receptors.
许多植物蛋白和一些植物病原体蛋白都被双重靶向到叶绿体和线粒体，并应该沿着细胞器蛋白输入的一般途径进行运输，但这个问题尚未得到探索。此外，细胞器转位通道受体存在几个成员的家族，它们在不同货物中的功能特化只是假设，而不是深入研究。本文就这些主题提供了新的见解，首次表明一种外源蛋白，即甜瓜坏死斑点病毒外壳蛋白，利用共同的Toc/Tom 导入系统进入线粒体和叶绿体，同时确定了涉及的特定受体。
