Fas 配体细胞内信号转导：PSTPIP 是否介导 T 细胞死亡？
Fas ligand intracellular signaling: does PSTPIP mediate T cell death?
机构信息
Laboratory of Immunoreceptors and signaling, Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
出版信息
Apoptosis. 2024 Feb;29(1-2):1-2. doi: 10.1007/s10495-023-01892-8. Epub 2023 Oct 4.
PMID:37794219
Abstract
Fas and Fas ligand (FasL)-induced cell death is critical for the appropriate regulation of immune responses, especially those mediated by T cells. In this letter, several studies are discussed that reinforce the importance of FasL intracellular signaling for CD4 + T cell death, which might involve PSTPIP phosphatase and/or MAPKs.
摘要
Fas 和 Fas 配体 (FasL) 诱导的细胞死亡对于免疫反应的适当调节至关重要，尤其是由 T 细胞介导的免疫反应。在这封信中，讨论了几项研究，这些研究强调了 FasL 细胞内信号传导对于 CD4+T 细胞死亡的重要性，这可能涉及 PSTPIP 磷酸酶和/或 MAPKs。
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